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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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1437-4331
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Volume 46, Issue 7 (Jul 2008)

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Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study

George V. Dedoussis
  • 1Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens, Greece
/ Stavroula Kanoni
  • 2Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens, Greece
/ Erminia Mariani
  • 3Laboratory of Immunology and Genetics, Istituto di Ricerca Codivilla-Putti, Bologna, Italy and Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
/ Luca Cattini
  • 4Laboratory of Immunology and Genetics, Istituto di Ricerca Codivilla-Putti, Bologna, Italy and Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
/ Georges Herbein
  • 5Department of Virology, Franche-Comte University, Besançon, France
/ Tamas Fulop
  • 6Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
/ Audrey Varin
  • 7Department of Virology, Franche-Comte University, Besançon, France
/ Lothar Rink
  • 8Institute of Immunology, RWTH-Aachen, Aachen, Germany
/ Jolanta Jajte
  • 9Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland
/ Daniela Monti
  • 10Department of Pathology and Oncology, University of Florence, Florence, Italy
/ Fiorela Marcellini
  • 11Immunology Centre (Section: Nutrition, Immunity and Ageing), Research Department INRCA, Ancona, Italy
/ Marco Malavolta
  • 12Immunology Centre (Section: Nutrition, Immunity and Ageing), Research Department INRCA, Ancona, Italy
/ Eugenio Mocchegiani
  • 13Immunology Centre (Section: Nutrition, Immunity and Ageing), Research Department INRCA, Ancona, Italy
Published Online: 2008-05-22 | DOI: https://doi.org/10.1515/CCLM.2008.191

Abstract

Background: Aging is associated with low-grade elevation of circulating inflammatory markers, leading to increased risk of morbidity and mortality. The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects.

Methods: Within the ZINCAGE study, 957 healthy old subjects (≥60 years old) from five European countries were recruited. Plasma interleukin (IL)-6, IL-8, monocyte chemoattractant protein, tumor necrosis factor-α, high-density lipoprotein cholesterol (HDL-C) and erythrocyte sedimentation rate (ESR) were measured. Dietary data were collected applying a food frequency questionnaire and were used to estimate adherence to the Mediterranean diet.

Results: The Italians presented the greatest adherence to the Mediterranean diet, while the Polish the poorest. In females, higher diet score was significantly associated with lower body mass index and ESR and higher HDL-C levels (β=−0.127, p=0.003; β=−0.144, p=0.001; β=0.144, p=0.029, respectively). In males, diet score was negatively associated with IL-8 levels (β=−0.101, p=0.044). The Mediterranean diet was associated with reduced IL-8 concentrations in Greeks (β=−0.213, p=0.007).

Conclusions: There were significant effects of the components of the Mediterranean diet on inflammation markers. The Mediterranean diet score is useful in assessing nutritional influence on immune status.

Clin Chem Lab Med 2008;46:990–6.

Keywords: elderly; inflammatory markers; Mediterranean diet; ZINCAGE study

About the article

Corresponding author: George V. Dedoussis, PhD, Assistant Professor of Biology, Department of Nutrition and Dietetics, Laboratory of Molecular Genetics, Harokopio University of Athens, 70 El. Venizelou str, 17671 Kallithea-Athens, Greece Phone: +30-210-9549304, Fax: +30-210-9577050,


Received: 2007-12-12

Accepted: 2008-03-20

Published Online: 2008-05-22

Published in Print: 2008-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.191. Export Citation

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