Clinical Chemistry and Laboratory Medicine (CCLM)
Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
Editor-in-Chief: Plebani, Mario
Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.
12 Issues per year
IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition
SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238
Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study
- 1Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens, Greece
- 2Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens, Greece
- 3Laboratory of Immunology and Genetics, Istituto di Ricerca Codivilla-Putti, Bologna, Italy and Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
- 4Laboratory of Immunology and Genetics, Istituto di Ricerca Codivilla-Putti, Bologna, Italy and Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
- 5Department of Virology, Franche-Comte University, Besançon, France
- 6Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
- 7Department of Virology, Franche-Comte University, Besançon, France
- 8Institute of Immunology, RWTH-Aachen, Aachen, Germany
- 9Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland
- 10Department of Pathology and Oncology, University of Florence, Florence, Italy
- 11Immunology Centre (Section: Nutrition, Immunity and Ageing), Research Department INRCA, Ancona, Italy
- 12Immunology Centre (Section: Nutrition, Immunity and Ageing), Research Department INRCA, Ancona, Italy
- 13Immunology Centre (Section: Nutrition, Immunity and Ageing), Research Department INRCA, Ancona, Italy
Background: Aging is associated with low-grade elevation of circulating inflammatory markers, leading to increased risk of morbidity and mortality. The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects.
Methods: Within the ZINCAGE study, 957 healthy old subjects (≥60 years old) from five European countries were recruited. Plasma interleukin (IL)-6, IL-8, monocyte chemoattractant protein, tumor necrosis factor-α, high-density lipoprotein cholesterol (HDL-C) and erythrocyte sedimentation rate (ESR) were measured. Dietary data were collected applying a food frequency questionnaire and were used to estimate adherence to the Mediterranean diet.
Results: The Italians presented the greatest adherence to the Mediterranean diet, while the Polish the poorest. In females, higher diet score was significantly associated with lower body mass index and ESR and higher HDL-C levels (β=−0.127, p=0.003; β=−0.144, p=0.001; β=0.144, p=0.029, respectively). In males, diet score was negatively associated with IL-8 levels (β=−0.101, p=0.044). The Mediterranean diet was associated with reduced IL-8 concentrations in Greeks (β=−0.213, p=0.007).
Conclusions: There were significant effects of the components of the Mediterranean diet on inflammation markers. The Mediterranean diet score is useful in assessing nutritional influence on immune status.
Clin Chem Lab Med 2008;46:990–6.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.