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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 46, Issue 8 (Aug 2008)


Insulin-like growth factor-I and complications of prematurity: a focus on bronchopulmonary dysplasia

Ettore Capoluongo
  • 1Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
/ Franco Ameglio
  • 2Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
/ Cecilia Zuppi
  • 3Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
Published Online: 2008-06-20 | DOI: https://doi.org/10.1515/CCLM.2008.211


At least four premature newborn complications have been reported to be associated with low serum insulin-like growth factor-I (IGF-I) levels: bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis and brain damage. Local IGF-I concentrations have only been reported for bronchopulmonary dysplasia and these findings show that lung IGF-I levels are clearly increased (epithelial lining fluid levels), emphasizing the fact that IGF-I is differently regulated in the general circulation or at local level. The present review discusses the meaning of the association between serum IGF-I amounts and development of complications in premature newborns. Finally, some methodological indications are reported regarding the IGF-I assay procedures. It is important to establish what are the possible relationships between blood levels and those of different compartments involved in the diseases.

Clin Chem Lab Med 2008;46:1061–6.

Keywords: brain damage; bronchoalveolar lavage fluid; bronchopulmonary dysplasia; insulin-like growth factor-I; necrotizing enterocolitis; prematurity; retinopathy of prematurity

About the article

Corresponding author: Ettore Capoluongo, PhD, Laboratory of Molecular Biology, Department of Biochemistry and Clinical Biochemistry, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy Phone: +39-0630154250, Fax: +39-0630156706,

Received: 2008-03-07

Accepted: 2008-03-27

Published Online: 2008-06-20

Published in Print: 2008-08-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2008.211. Export Citation

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