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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

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1437-4331
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In This Section
Volume 47, Issue 10 (Oct 2009)

Issues

Evaluation of a new method for the diagnosis of alterations of Lens culinaris agglutinin binding of thyroglobulin molecules in thyroid carcinoma

Toshiharu Kanai
  • Division of Breast and Endocrine Surgery, Department of Surgery (II), Shinshu University School of Medicine, Matsumoto, Japan
/ Masao Amakawa
  • Department of Medical Technology, Kagawa Prefectural College of Health Sciences, Takamatsu, Kagawa, Japan
/ Ryoji Kato
  • Department of Medical Technology, Kagawa Prefectural College of Health Sciences, Takamatsu, Kagawa, Japan
/ Kayoko Shimizu
  • Diagnostics Reseach Laboratories, Wako Pure Chemical Industries Ltd, Japan
/ Kenji Nakamura
  • Diagnostics Reseach Laboratories, Wako Pure Chemical Industries Ltd, Japan
/ Ken-ichi Ito
  • Division of Breast and Endocrine Surgery, Department of Surgery (II), Shinshu University School of Medicine, Matsumoto, Japan
/ Yoshihisa Hama
  • Division of Breast and Endocrine Surgery, Department of Surgery (II), Shinshu University School of Medicine, Matsumoto, Japan
/ Minoru Fujimori
  • Department of Breast Surgery, Tokyo Medical University, Kasumigaura Hospital, Ami, Japan
/ Jun Amano
  • Division of Breast and Endocrine Surgery, Department of Surgery (II), Shinshu University School of Medicine, Matsumoto, Japan
Published Online: 2009-09-11 | DOI: https://doi.org/10.1515/CCLM.2009.277

Abstract

Background: The measurement of serum thyroglobulin (Tg) is widely used as a marker for recurrence of thyroid carcinoma following total thyroidectomy. However, this method cannot differentiate between benign and malignant disease. We focused on the sugar chain in the Tg molecule and investigated the usefulness of Lens culinaris agglutinin (LCA)-reactive Tg ratios in sera and wash fluids obtained during fine-needle aspiration (FNA) for the detection of thyroid carcinoma.

Methods: The study was performed using 203 serum samples (115 from patients with benign thyroid disease and 88 from patients with thyroid carcinomas) and 176 wash fluid samples (143 benign, 21 malignant, and 12 inconclusive). LCA-reactive Tg ratios were determined using an enzyme-linked immunosorbent assay, and a comparison was made between malignant and benign lesions.

Results: In serum, the ratio in patients with malignancy was 79.5±6.0 [mean±standard deviation (SD)], significantly lower than in patients with benign lesions (84.9±3.5). The ratios in wash fluid from malignant lesions (75.8±18.9) were also significantly lower than those from benign lesions (85.6±3.9).

Conclusions: These results suggest that this method could distinguish between benign and malignant lesions and may be useful for screening serum and wash samples.

Clin Chem Lab Med 2009;47:1285–90.

Keywords: Lens culinaris agglutinin; sugar chain; thyroglobulin; thyroid carcinoma

About the article

Corresponding author: Toshiharu Kanai, Division of Breast and Endocrine Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan Phone: +81 263 37 2657, Fax: +81 263 37 2721,


Received: 2009-04-20

Accepted: 2009-06-30

Published Online: 2009-09-11

Published in Print: 2009-10-01



Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.277. Export Citation

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