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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 47, Issue 11


Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer – evaluation of the prognostic significance of these agents

Stanislaw Sulkowski / Andrzej Wincewicz / Bogdan Zalewski
  • Department of General and Gastrointestinal Surgery, Medical University of Bialystok, Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Waldemar Famulski / Joanna Maria Lotowska / Mariusz Koda / Maria Elzbieta Sobaniec-Lotowska / Michal Mysliwiec
  • Department of Nephrology and Transplantology, Medical University of Bialystok, Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marek Baltaziak / Krystyna Pawlak
  • Department of Nephrology and Transplantology, Medical University of Bialystok, Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mariola Sulkowska
Published Online: 2009-10-12 | DOI: https://doi.org/10.1515/CCLM.2009.305


Background: Insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) belong to a group of hypoxia related proteins. IGF-I induces expression of VEGF and decomposes wild type p53 in cancer cell lines. The goal of our study was to evaluate serum IGF-I, VEGF and p53 with respect to overall and disease free survival of patients with colorectal cancer (CRC) patients compared with healthy volunteers.

Methods: Preoperative blood samples from 125 patients with CRC and 16 healthy volunteers were examined using ELISA for serum IGF-I, p53 and VEGF concentrations.

Results: Concentrations of p53 and VEGF were significantly higher in CRC patients than in controls (p<0.0006 and p<0.0001, respectively). IGF-I was not statistically different between both groups. Serum IGF-I showed negative correlation with p53 in CRC patients (p<0.04, r=−0.193). IGF-I and VEGF showed negative correlation in poorly differentiated cancers (G3) (p<0.03, r=−0.339). Patients with VEGF concentrations that were above average for the cancer population survived for a shorter period of time (p=0.065 in evaluation of overall survival and 0.071 in estimation of disease-free survival during a 3-year follow-up) compared with patients with serum VEGF lower than the highest values seen in controls.

Conclusions: Comparisons between serum IGF-I and p53 appear to confirm the metabolism of p53 by IGF-I. Serum VEGF showed prognostic significance in our study. Serum concentrations of IGF-I and VEGF did not show positive correlation, as expected due to IGF-I induction of VEGF in malignant colon cell lines.

Clin Chem Lab Med 2009;47:1439–45.

Keywords: colorectal cancer; insulin-like growth factor-I; p53; serum; vascular endothelial growth factor

About the article

Corresponding author: Andrzej Wincewicz, MD, PhD, Department of Medical Pathomorphology, Medical University of Bialystok, Waszyngtona St 13, 15-269 Bialystok, Poland Phone: +4885 748 59 45, Fax: +4885 748 59 44,

Received: 2009-06-08

Accepted: 2009-07-22

Published Online: 2009-10-12

Published in Print: 2009-11-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 11, Pages 1439–1445, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.305.

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