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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 47, Issue 11


The rate of manual peripheral blood smear reviews in outpatients

Paul Froom / Rosa Havis / Mira Barak
Published Online: 2009-09-25 | DOI: https://doi.org/10.1515/CCLM.2009.308


Background: The International Consensus Group for Hematology Review recommends manual blood smears for new findings from automated complete blood cell (CBC) tests. However, in outpatients, the rate of peripheral manual blood smear reviews is uncertain, as is the effect of historical results on this rate.

Methods: In a prospective cohort study of 687,955 members of a health maintenance organization, we extracted 39,759 consecutive automated CBC test results and determined the rate of manual peripheral smear reviews that were indicated using different triggering criteria, and historical results.

Results: Individual triggering values increased from 10.7% to 19.5% when comparing our criteria to those of the consensus criteria. The proportion of CBC test results with at least one triggering value was 7.2% using our criteria, compared to 13.9% with the inclusion of a mean corpuscular volume <75 and a plus one immature granulocyte flag according to the consensus committee. Availability of historical data decreased our peripheral smear review rate to 2.6%.

Conclusions: The peripheral smear review rate in outpatients using the consensus criteria was higher than with our less stringent criteria. If historical data are available and no clinical utility is demonstrated for the additional consensus criteria, an acceptable out-patient review rate might be as low as 2.6%.

Clin Chem Lab Med 2009;47:1401–5.

Keywords: manual; outpatient; peripheral; smear review; triggering values

About the article

Corresponding author: Professor P. Froom, MD, Head of the Hematology Laboratory, Central Laboratory of Haifa and Western Galilee, Clalit Health Services, Nesher, Israel Phone: +972-4-6394470, Fax: +972-4-6243302,

Received: 2009-05-17

Accepted: 2009-07-23

Published Online: 2009-09-25

Published in Print: 2009-11-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 11, Pages 1401–1405, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.308.

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