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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
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1437-4331
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Volume 47, Issue 12 (Dec 2009)

Issues

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Carla Estaquio
  • Unité de Surveillance et d'Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Université Paris 13, Cnam, Centre de Recherche en Nutrition Humaine (CRNH) Ile-de-France, Bobigny, France
  • UMR U557 INSERM, U1125 INRA, CNAM, Paris 13, CRNH Ile-de-France, Bobigny, France
  • Other articles by this author:
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/ Pierre Valeix
  • Unité de Surveillance et d'Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Université Paris 13, Cnam, Centre de Recherche en Nutrition Humaine (CRNH) Ile-de-France, Bobigny, France
  • UMR U557 INSERM, U1125 INRA, CNAM, Paris 13, CRNH Ile-de-France, Bobigny, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laurence Leenhardt
  • Département Maladies Chroniques et Traumatismes, Institut de Veille Sanitaire, Saint-Maurice, France
  • Service de Médecine Nucléaire, Hôpital Pitié-Salpêtrière, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elizabeth Modigliani / Marie-Christine Boutron-Ruault / Laurence Chérié-Challine
  • Département Maladies Chroniques et Traumatismes, Institut de Veille Sanitaire, Saint-Maurice, France
  • Other articles by this author:
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/ Marguerite Legrand / Serge Hercberg
  • Unité de Surveillance et d'Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Université Paris 13, Cnam, Centre de Recherche en Nutrition Humaine (CRNH) Ile-de-France, Bobigny, France
  • UMR U557 INSERM, U1125 INRA, CNAM, Paris 13, CRNH Ile-de-France, Bobigny, France
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/ Katia Castetbon
  • Unité de Surveillance et d'Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Université Paris 13, Cnam, Centre de Recherche en Nutrition Humaine (CRNH) Ile-de-France, Bobigny, France
  • UMR U557 INSERM, U1125 INRA, CNAM, Paris 13, CRNH Ile-de-France, Bobigny, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-11-02 | DOI: https://doi.org/10.1515/CCLM.2009.334

Abstract

Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT4) based on data collected from a disease-free sample of French middle-aged adults.

Methods: A total of 3218 subjects participating in the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) study had measurements for TSH, fT4 and urinary iodine concentrations. Thyroid volume and structure were evaluated using standardized ultrasonography. We selected a disease-free sample which included 2338 subjects (1313 females aged 35–60 years and 1025 males aged 45–60 years) with normal thyroid imaging, no previously reported thyroid disease or use of thyroid medication, and no risk factors for thyroid dysfunction. Distribution of TSH and fT4 was estimated in males and females.

Results: The median (central 95% range) TSH serum concentrations for females were 1.79 mU/L (0.29–5.21 mU/L) for ages 35–44 years and 1.98 mU/L (0.27–6.94 mU/L) for ages 45–60 years (p<0.0001, for age). The median (central 95% range) for males 45–60-year-old was 1.63 mU/L (0.28–4.54 mU/L) (p<0.0001, for sex). Sex- and age-specific mean fT4 concentrations did not differ significantly (p=0.06) between males and females and (p=0.08) between female age groups. However, median fT4 concentrations between 45–60-year-old males and females differed (p<0.001).

Conclusions: In middle-aged adults, the TSH distribution was associated with gender and, among females, with age. Stratification according to gender and age should be considered when TSH ranges are used in the diagnosis, treatment and monitoring of thyroid disease.

Clin Chem Lab Med 2009;47:1497–505.

Keywords: adults; free thyroxin; ranges; thyrotropin; ultrasonography

About the article

Corresponding author: Katia Castetbon, Unité de Surveillance et d'Epidémiologie Nutritionnelle, InVS-Paris 13-Cnam 74 rue Marcel Cachin, 93017 Bobigny Cedex, France Phone: +33 (0)1 48 38 73 73, Fax: +33 (0)1 48 38 73 74,


Received: 2009-04-15

Accepted: 2009-08-21

Published Online: 2009-11-02

Published in Print: 2009-12-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.334.

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©2009 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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