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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 47, Issue 12


Appropriate utilization of clinical laboratory tests

María Concepción Alonso-Cerezo / José Simón Martín
  • Instituto Universitario de Evaluación Sanitaria, Facultad de Medicina, Universidad Complutense, Ciudad Universitaria, Madrid, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Miguel Angel García Montes / Verónica Marcos de la Iglesia
  • Chemistry Servicio de Análisis Clínicos, Hospital Universitario de La Princesa, Madrid, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-10-28 | DOI: https://doi.org/10.1515/CCLM.2009.335


Background: The use of laboratory tests has been increasing in recent years due to various factors affecting laboratories, physicians, legal aspects, or patients themselves.

Methods: The efficacy of laboratory tests must be evaluated on the basis of the clinical benefits that they provide in terms of prevention, diagnosis, follow-up, or treatment; with the aim of optimizing health results in general.

Results: There are techniques that can be used to determine the clinical validity of the efficacy, effectiveness, and safety of treatment or preventive measures performed on individuals with abnormal tests, as well as providing an economic evaluation of the process. Once the test is incorporated into clinical service, it must be evaluated by retrospective audits in test utilization. To improve the use of laboratory tests, many strategies have been devised that incorporate clinical practice guidelines (CPGs), the conduct of professionals and the patients, and organization of the process. We discuss the importance of the involvement of health professionals.

Conclusions: Strategies in relation to CPGs, conduct of professionals, conduct of patients, or organization of health care processes improve the use of tests in relation to clinical processes. Laboratory professionals have the appropriate knowledge and can improve the quality and efficacy of health care.

Clin Chem Lab Med 2009;47:1461–5.

Keywords: appropriate use; efficacy; improvement; laboratory professionals; laboratory results

About the article

Corresponding author: Alonso-Cerezo María Concepción, MD, PhD, Servicio de Análisis Clínicos, Hospital Universitario de La Princesa, c/ Diego de León, 62, 28006 Madrid, Spain Phone: +34 91 520 22 49, Fax: +34 91 520 22 17,

Received: 2009-03-28

Accepted: 2009-08-14

Published Online: 2009-10-28

Published in Print: 2009-12-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 12, Pages 1461–1465, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.335.

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