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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

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1437-4331
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Volume 47, Issue 12 (Dec 2009)

Issues

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Jayong Chung
  • Department of Food and Nutrition and Research Institute of Science for Human Life, College of Human Ecology, Kyung Hee University, Seoul, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Se-Young Oh
  • Department of Food and Nutrition and Research Institute of Science for Human Life, College of Human Ecology, Kyung Hee University, Seoul, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ You-Kyung Shin
  • Department of Food and Nutrition and Research Institute of Science for Human Life, College of Human Ecology, Kyung Hee University, Seoul, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-10-21 | DOI: https://doi.org/10.1515/CCLM.2009.336

Abstract

Background: Glutathione S-transferase (GST) enzymes are critical for detoxifying reactive oxygen species (ROS) and their products which have been implicated in the pathology of inflammatory diseases such as atopic dermatitis (AD).

Methods: We investigated the effects of genetic polymorphisms of GST on the risk of AD in preschool age children. Biomarkers for oxidative stress were also evaluated with respect to GST genotype.

Results: The GSTP1 Val105 allele was significantly associated with an increased risk of AD [odds ratio (OR)=1.62, p<0.05]. The combination of the GSTP1 Val105 allele and the GSTT1 null genotype further increased this risk by 2.3-fold (p<0.01). No association was observed for the GSTM1 null or GSTT1 null genotype alone. In children with AD, blood total antioxidant capacity was significantly less (p<0.001), while malondialdehyde was higher (p=0.12). Children with the GSTP1 Val105 allele had significantly lower concentrations of erythrocyte glutathione compared to GSTP1 Ile/Ile homozygotes (p=0.03).

Conclusions: Our study suggests that the GSTP1 Val105 allele is an important determinant of susceptibility to AD in preschool age children and increased oxidative stress may play a role in the pathogenesis of AD.

Clin Chem Lab Med 2009;47:1475–81.

Keywords: atopic dermatitis; glutathione-S-transferase; oxidative stress; polymorphism; preschool age children

About the article

Corresponding author: Jayong Chung, PhD, Department of Food and Nutrition Kyung Hee University, Hoegi-dong 1, Dongdaemun-gu, Seoul 130-701, Korea Phone: +82-2-961-0977, fax: +82-2-968-0260,


Received: 2009-04-05

Accepted: 2009-08-05

Published Online: 2009-10-21

Published in Print: 2009-12-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.336.

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©2009 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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