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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 47, Issue 12 (Dec 2009)

Issues

Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese

Bing Xiao
  • State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China
  • Department of Cellular and Molecular Biology, Shanghai Institute of Hypertension, Shanghai, P.R. China
/ Yi Zhang
  • State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China
  • Department of Cellular and Molecular Biology, Shanghai Institute of Hypertension, Shanghai, P.R. China
  • Sino-French Research Center for Life Science and Genomics, Shanghai, P.R. China
/ Wen-quan Niu
  • State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China
  • Department of Cellular and Molecular Biology, Shanghai Institute of Hypertension, Shanghai, P.R. China
/ Pin-jing Gao
  • State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China
  • Department of Cellular and Molecular Biology, Shanghai Institute of Hypertension, Shanghai, P.R. China
  • Shanghai Key Laboratory of Vascular Biology, Shanghai, P.R. China
  • Laboratory of Vascular Biology, Institute of Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China
/ Ding-liang Zhu
  • State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China
  • Department of Cellular and Molecular Biology, Shanghai Institute of Hypertension, Shanghai, P.R. China
  • Shanghai Key Laboratory of Vascular Biology, Shanghai, P.R. China
  • Sino-French Research Center for Life Science and Genomics, Shanghai, P.R. China
Published Online: 2009-10-28 | DOI: https://doi.org/10.1515/CCLM.2009.344

Abstract

Background: A recent genome-wide linkage study mapped blood pressure (BP)-related loci on human chromosome 1q and identified the regulator of G-protein signaling 5 (RGS5) as a candidate for regulation of BP. Thus, we assessed the relationship between RGS5 genetic polymorphisms and essential hypertension (EH) in Chinese.

Methods: A total of 906 patients with EH and 894 age- and gender-matched normotensive (NT) controls were enrolled. Sixteen single nucleotide polymorphisms (SNPs) in RGS5 were genotyped.

Results: There were no significant differences in the overall distributions of the genotypic and allelic frequencies for each SNPs between the two groups. However, in haplotype analysis, significant differences for the overall distributions were noted for four haplotypes constructed by five SNPs (rs12041294C/T, rs10917690A/G, rs10917695T/C, rs10917696T/C and rs2662774G/A), viz. H2 (C–A–C–T–A) (p=0.038), H5 (C–G–T–T–G) (p=0.001), H6 (T–G–C–T–A) (p=0.021) and H12 (T–A–T–T–G) (p=0.023). Serum concentrations of high- and low-density lipoprotein cholesterol showed significant associations with haplotypes revealed by a global test (p=0.0001 and 0.0309).

Conclusions: Multiple SNPs in combination in RGS5 may confer risk for hypertension. Our results also lend support for the effect of RGS5 SNPs on lipid metabolism. Further studies are warranted to find the causal SNPs in RGS5 for EH.

Clin Chem Lab Med 2009;47:1483–8.

Keywords: haplotypes; hypertension; polymorphism; RGS5

About the article

Corresponding author: Prof. Ding-liang Zhu, Shanghai Institute of Hypertension, 197 Ruijin 2nd Road, Shanghai 200025, P.R. China Phone/Fax: +86 21 54654498,


Received: 2009-04-23

Accepted: 2009-09-03

Published Online: 2009-10-28

Published in Print: 2009-12-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.344.

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©2009 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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