Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

See all formats and pricing
More options …
Volume 47, Issue 12


Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients

Natheer H. Al-Rawi / Karim M. Atiyah
Published Online: 2009-10-30 | DOI: https://doi.org/10.1515/CCLM.2009.345


Background: The blood-brain barrier is compromised in patients with stroke. The release of neuro-biochemical protein markers, such as neuron specific enolase (NSE) into the circulation may allow the pathophysiology and prognosis of patients with cerebrovascular diseases to be evaluated further. The present study was designed to measure the marker of neuronal damage, NSE, in saliva and serum of patients with acute ischemic stroke and patients with stroke related diseases as a diagnostic and/or monitoring tool for early prediction of ischemic stroke.

Methods: Salivary and serum NSE concentrations were measured in 150 individuals. Fifty were patients recently diagnosed as having ischemic stroke, 75 were gender and age-matched risk-group patients (patients with hypertension, type 2 diabetes and ischemic heart disease). Another 25 were gender and age-matched healthy controls.

Results: Salivary and serum NSE concentrations were significantly higher than that of healthy controls. The cut-off threshold for salivary NSE of 3.7 μg/L was optimum, showing 80% accuracy for differentiation of ischemic stroke from normal individuals.

Conclusions: Salivary NSE (alone or in combination with serum) can be used as a valuable diagnostic and possibly prognostic tool for measurement of neuronal damage in patients with stroke and stroke-related diseases.

Clin Chem Lab Med 2009;47:1519–24.

Keywords: cerebrovascular accident; neuron specific enolase; neuronal damage marker; saliva; stroke

About the article

Corresponding author: Natheer H. Al-Rawi, Assistant Professor, College of Dentistry, University of Sharjah, Sharjah, UAE

Received: 2009-05-14

Accepted: 2009-07-30

Published Online: 2009-10-30

Published in Print: 2009-12-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 12, Pages 1519–1524, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.345.

Export Citation

©2009 by Walter de Gruyter Berlin New York.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

I. A. Kadyrova and A. S. Kadyrov
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2016, Volume 116, Number 11, Page 92
Wesley K. Lefferts, Matthew C. Babcock, Matthew J. Tiss, Stephen J. Ives, Corey N. White, Tom D. Brutsaert, and Kevin S. Heffernan
Physiology & Behavior, 2016, Volume 165, Page 108
Alina González-Quevedo, Sergio González-García, Zenaida Hernández-Díaz, Otman Fernández Concepción, Luis Quevedo Sotolongo, Marisol Peña-Sánchez, Benjamín Márquez Rosales, Rosaralis Santiesteban Freixas, Isabel Fernández-Almirall, María Caridad Menéndez-Sainz, and Rebeca Fernández-Carriera
Journal of the Neurological Sciences, 2016, Volume 363, Page 158
Harsh Vardhan Singh, Aparna Pandey, Amit Kumar Shrivastava, Arun Raizada, Sanjeev Kumar Singh, and Neelima Singh
Clinica Chimica Acta, 2013, Volume 419, Page 136
Sergio González-García, Alina González-Quevedo, Otman Fernández-Concepción, Marisol Peña-Sánchez, Caridad Menéndez-Saínz, Zenaida Hernández-Díaz, Marianela Arteche-Prior, Alejandro Pando-Cabrera, and Carlos Fernández-Novales
Clinical Biochemistry, 2012, Volume 45, Number 16-17, Page 1302
Alina González-Quevedo, Sergio González García, Otman Fernández Concepción, Rosaralis Santiesteban Freixas, Luis Quevedo Sotolongo, Maria Caridad Menéndez, Marisol Peña Sánchez, Isabel Fernández Almirall, Rebeca Fernández Carriera, Zenaida Hernández Díaz, and Keiny Menéndez
Clinical Biochemistry, 2011, Volume 44, Number 2-3, Page 154

Comments (0)

Please log in or register to comment.
Log in