Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 47, Issue 12 (Dec 2009)

Issues

Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

Yasemin Gulcan Kurt / Tuncer Cayci / Pinar Onguru
  • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ E. Ozgur Akgul / Halil Yaman / Ibrahim Aydin / Hurrem Bodur
  • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Turker Turker / Ismail Kurt / M. Aydin Cevik
  • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ M. Kemal Erbil

Abstract

Background: Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mortality.

Methods: ChT activities on the first day of hospitalization were analyzed in serum from 46 patients with CCHF and 36 healthy controls. Serum ChT activities and other clinical and laboratory parameters for patients with non-fatal and fatal CCHF were compared.

Results: The median ChT activity was increased in all patients with CCHF [189.9 (134.8–246.6) nmol/mL/h]. The median ChT activity in the non-fatal CCHF group [220.2 (180.6–290.1) nmol/mL/h] was higher compared with the fatal CCHF group [29.2 (16.5–45.7) nmol/mL/h] (p<0.001). In univariate analysis, platelet count, lactate dehydrogenase (LDH), and activated partial thromboplastin time were associated with mortality.

Conclusions: This is the first study investigating the association of serum ChT enzyme activity with mortality from CCHF. This study suggested that relatively low ChT enzyme activities may be a prognostic marker in patients with CCHF.

Clin Chem Lab Med 2009;47:1543–7.

Keywords: chitotriosidase enzyme activity; Crimean-Congo hemorrhagic fever; mortality

About the article

Corresponding author: Halil Yaman, Department of Medical Biochemistry, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey Phone: +90 312 3043319, Fax: +90 312 3043300, ;


Received: 2009-03-25

Accepted: 2009-09-08

Published in Print: 2009-12-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.347.

Export Citation

©2009 by Walter de Gruyter Berlin New York. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Halef Okan Doğan, Ahmet Omma, Turan Turhan, Nihal Boğdaycıoğlu, Yaşar Karaaslan, Hayrettin Yavuz, Özlem Demirpençe, Hüseyin Aydın, and Sevtap Bakır
Journal of Korean Medical Science, 2016, Volume 31, Number 12, Page 1902
[2]
C. Sanfilippo, G. Nunnari, A. Calcagno, L. Malaguarnera, K. Blennow, H. Zetterberg, and M. Di Rosa
Virus Research, 2017, Volume 227, Page 220
[3]
Esragul Akinci, Hurrem Bodur, Mustafa Sunbul, and Hakan Leblebicioglu
Antiviral Research, 2016, Volume 132, Page 233
[4]
Mohamed A. Elmonem, Lambertus P. van den Heuvel, and Elena N. Levtchenko
Enzyme Research, 2016, Volume 2016, Page 1
[5]
Gulhan Cakır, Seyfettin Gumus, Ergun Ucar, Hatice Kaya, Ergun Tozkoparan, Emin Ozgur Akgul, Bulent Karaman, Omer Deniz, Ismail Kurt, Metin Ozkan, and Hayati Bilgic
Annals of Laboratory Medicine, 2012, Volume 32, Number 3, Page 184

Comments (0)

Please log in or register to comment.
Log in