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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 47, Issue 2


Vitamin D: current status and perspectives

Etienne Cavalier / Pierre Delanaye / Jean-Paul Chapelle / Jean-Claude Souberbielle
  • 4Université Paris Descartes, Inserm U845, and Hôpital Necker, Service d'explorations fonctionnelles, Paris, France
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Published Online: 2008-12-22 | DOI: https://doi.org/10.1515/CCLM.2009.036


The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25-OH vitamin D into its most active metabolite, 1,25-(OH)2 vitamin D, has led to a very promising future for this “old” molecule. Indeed, observational studies, and more and more interventional studies, are raising the importance of a significant vitamin D supplementation for not-only skeletal benefits. Among them, 25-OH vitamin D has been found to play an important role in prevention of cancers, auto-immune diseases, cardiovascular diseases, diabetes, and infections. Vitamin D deficiency, defined as serum 25-OH vitamin D levels <30 ng/mL, is very common in our population. The cost/benefit ratio and some recently published studies are clearly now in favor of a controlled and efficient vitamin D supplementation in these patients presenting a 25-OH vitamin D level <30 ng/mL. More attention should also be focused on pregnant and lactating women, as well as children and adolescents.

Clin Chem Lab Med 2009;47:120–7.

Keywords: deficiency; new insights; non-skeletal actions; vitamin D

About the article

Corresponding author: Dr. Etienne Cavalier, Department of Clinical Chemistry, University Hospital of Liege, University of Liege, Domaine du Sart-Tilman, 4000 Liège, Belgium Phone: +32-4-3667692, Fax: +32-4-3667691,

Received: 2008-04-01

Accepted: 2008-10-11

Published Online: 2008-12-22

Published in Print: 2009-02-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 2, Pages 120–127, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.036.

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