Clinical Chemistry and Laboratory Medicine (CCLM)
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Vitamin B12 deficiency is associated with coronary artery disease in an Indian population
- 1Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, Delhi, India
- 2Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, Delhi, India
- 3Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, Delhi, India
- 4Human Genetics Unit, Indian Statistical Institute, B.T. Road, Kolkata, India
- 5Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
- 6Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
- 7Human Genetics Unit, Indian Statistical Institute, B.T. Road, Kolkata, India
- 8Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, Delhi, India
Background: The incidence of coronary artery disease (CAD) is increasing at an alarming rate, especially in developing countries, such as India. It is often advocated that a vegetarian lifestyle could reduce the burden of CAD. However, in spite of a majority of Indians being vegetarians, the incidence of CAD is highest in this population. This may be due to deficiency of vitamin B12, a micronutrient, sourced only from animal products.
Methods: Herein, we assessed the effect of vitamin B12 with respect to CAD in 816 individuals (368 CAD patients and 448 controls) recruited from a tertiary care center in New Delhi, India.
Results: We found that vitamin B12 levels were significantly lower in CAD patients than in controls (p<0.0001). Also, vegetarians were found to have significantly lower vitamin B12 concentrations (p=0.0001) and higher incidence of CAD (p=0.01). Interestingly, elevated homocysteine levels, a hallmark of vitamin B12 deficiency, was not associated with CAD. In contrast, cysteine levels were significantly higher in CAD patients than in controls (p=0.004).
Conclusions: We believe that, when vitamin B12 is deficient, homocysteine is rapidly metabolized via the transsulfuration pathway leading to increased cysteine levels.
Clin Chem Lab Med 2009;47:334–8.
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