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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma

Chi-Chung Chang1 / Shu-Chen Chen2 / Yi-Hsien Hsieh3 / Yi-Chen Chen4 / Tzy-Yen Chen5 / Yin-Hung Chu1 / Hui-Jen Ma1 / Ming-Chih Chou1 / Hsiu-Ting Tsai6 / Shun-Fa Yang7

1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

2Department of Nursing, Central Taiwan University of Science and Technology and Institute of Medicine, School of Nursing, Chung Shan Medical University, Taichung, Taiwan

3Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan

4School of Nutrition, Chung Shan Medical University, Taichung, Taiwan

5Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

6School of Nursing, Chung Shan Medical University, Taichung, Taiwan

7Institute of Medicine, Chung Shan Medical University and Department of Medical Research, Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan

Corresponding authors: Shun-Fa Yang, PhD, and Hsiu-Ting Tsai, PhD, Institute of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo N. Road, Taichung, Taiwan, ROC Phone: +886-4-24739595 #34253, Fax +886-4-24723229, (S.-F. Yang), (H.-T. Tsai)

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 4, Pages 412–418, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.092, April 2009

Publication History

Received:
2008-09-23
Accepted:
2009-01-05

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide. Genetic polymorphism has been reported as a predictive factor related to a higher risk for HCC. Because the stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been reported to play important roles in tumor cell proliferation, angiogenesis, and metastasis of HCC, the aim of this study was to estimate the relationship between SDF-1 and CXCR4 gene variants to HCC risk and clinicopathological status.

Methods: Polymerase chain reaction-restriction fragment length polymorphism was used to measure SDF-1 (rs1801157) and CXCR4 (rs2228014) gene polymorphisms in 311 healthy controls and 102 patients with HCC.

Results: Compared to controls, individuals with at least one A allele had a higher risk of 1.57-fold (95% CI: 1.00–2.47) to induce HCC and had a risk of 2.81-fold (95% CI: 1.04–7.58) to develop a status of stage III or stage IV disease, after being adjusted for other confounders. However, there was no significant association between CXCR4 gene polymorphism and either HCC risk or pathological status. Additionally, both gene polymorphisms were not associated with the serum expression of liver-related clinical pathological markers.

Conclusions: SDF-1–3′A gene polymorphism could be considered as a factor related to an increased susceptibility to the risk and pathological development of HCC.

Clin Chem Lab Med 2009;47:412–8.

Keywords: CXCR4; hepatocellular carcinoma (HCC); single nucleotide polymorphism (SNP); stromal cell-derived factor-1 (SDF-1)

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