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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 47, Issue 4

Issues

Lipoprotein(a) level and its association with tumor stage in male patients with primary lung cancer

Hai-hua Yang
  • Department of Radiotherapy, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Xiao-feng Chen
  • Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wei Hu
  • Department of Radiotherapy, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dong-qing Lv
  • Department of Pulmonary Medicine, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wei-jun Ding
  • Department of Radiotherapy, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Li-jiang Tang
  • Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jian-jun Jiang
  • Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Min-hua Ye
  • Department of Thoracic Surgery, Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-02-18 | DOI: https://doi.org/10.1515/CCLM.2009.094

Abstract

Background: Recently, attention has been focused on the effect of lipoprotein(a) [Lp(a)] on tumors because of its possible role in development of tumor angiogenesis. The aim of this study was to investigate Lp(a) serum levels in patients with lung cancer and its association with the stages of disease.

Methods: Fasting venous blood samples were collected from 418 untreated male patients with stages I–IV lung carcinoma and were analyzed for Lp(a). The results were compared with the data from 65 healthy male controls.

Results: Lp(a) levels were elevated (median 157 mg/L, range 16–1497 mg/L) in patients with lung carcinoma compared to control subjects (median 110 mg/L, range 35–706 mg/L) (p=0.004). Subgroup analysis showed that patients with stages II–IV disease had significantly higher Lp(a) concentrations than did healthy controls (p<0.05). There was an independently positive correlation between tumor stage and Lp(a) levels among patients with stages I–III (r=0.162, p=0.006). However, there was a decrease in Lp(a) in stage IV compared to stage III patients (p=0.03).

Conclusions: There is a significant association between Lp(a) and the presence and stage of lung cancer. Additional investigations with a larger number of lung cancer patients are needed to confirm these findings.

Clin Chem Lab Med 2009;47:452–7.

Keywords: lipids; lipoprotein(a); lung carcinoma; stage

About the article

Corresponding author: Xiao-feng Chen, Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College, Taizhou, 317000, Zhejiang, China Phone: +86-138-19639007, Fax: +86-576-85199876,


Received: 2008-10-03

Accepted: 2009-01-05

Published Online: 2009-02-18

Published in Print: 2009-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 4, Pages 452–457, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.094.

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