Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982

Online
ISSN
1437-4331
See all formats and pricing
In This Section
Volume 47, Issue 4 (Apr 2009)

Issues

Genotype distribution of estrogen receptor α polymorphisms in pregnant women from healthy and preeclampsia populations and its relation to blood pressure levels

Juan Zhang
  • Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Sichuan, PR China
/ Huai Bai
  • Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Sichuan, PR China
/ Xinghui Liu
  • Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Sichuan, PR China
/ Ping Fan
  • Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Sichuan, PR China
/ Rui Liu
  • Division of Peptides Related with Human Disease, West China Hospital, Sichuan University, Sichuan, PR China
/ Yi Huang
  • Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Sichuan, PR China
/ Xiaosu Wang
  • Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Sichuan, PR China
/ Guolin He
  • Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Sichuan, PR China
/ Yu Liu
  • Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan, PR China
/ Bingwen Liu
  • Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan, PR China
Published Online: 2009-03-02 | DOI: https://doi.org/10.1515/CCLM.2009.096

Abstract

Background: The estrogen receptor α gene (ESR1) seems to be a potential candidate in altering risk for preeclampsia due to important estrogenic biological effects. Despite its previously reported association with severe preeclampsia in combined genotype in one selected ethnic group, further studies in other populations are required. The objective of this study was to investigate the relationship of the gene polymorphisms of the estrogen receptor α with preeclampsia in a southwest Chinese population.

Methods: We genotyped two polymorphisms in the ESR1 gene (PvuII and XbaI) by polymerase chain reaction-restriction fragment length polymorphism analysis in a Chinese population.

Results: In the case-control study which included 204 preeclampsia case subjects and 236 normal control subjects, the frequencies of allele T for the PvuII site and allele G for the XbaI site in the patients (41.67% and 23.53%, respectively) were similar to those observed in controls (43.01% and 19.70%, respectively). Furthermore, the combined genotype analysis of ESR1 PvuII and XbaI polymorphisms showed no increased risk of either severe or total preeclampsia in our study populations. However, it showed that the CC homozygotes and CT heterozygotes in control pregnant women had higher systolic blood pressure levels than TT homozygotes for the PvuII site after adjustment for age and body mass index (p<0.05).

Conclusions: Our work does not provide evidence in favor of ESR1 PvuII and XbaI being associated with preeclampsia but with increased blood pressure levels in normal pregnant women, in a southwest Chinese population.

Clin Chem Lab Med 2009;47:391–7.

Keywords: estrogen receptor α gene (ESR1); polymorphism; preeclampsia; pregnancy induced hypertension

About the article

Corresponding author: Dr. Huai Bai, Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China Phone: +86-28-85503259, Fax: +86-28-85559065,


Received: 2008-10-09

Accepted: 2009-01-05

Published Online: 2009-03-02

Published in Print: 2009-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.096.

Export Citation

©2009 by Walter de Gruyter Berlin New York. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Xiaoyu Dai, Chao Wang, Jin Dai, Dongquan Shi, Zhihong Xu, Dongyang Chen, Huajian Teng, and Qing Jiang
BioMed Research International, 2014, Volume 2014, Page 1
[2]
T. Groten, E. Schleussner, T. Lehmann, F. Reister, B. Holzer, K. A. Danso, and R. Zeillinger
Archives of Gynecology and Obstetrics, 2014, Volume 289, Number 3, Page 581
[3]
Balázs Stenczer, János Rigó Jr, Zoltán Prohászka, Zoltán Derzsy, Levente Lázár, Veronika Makó, László Cervenak, Krisztián Balogh, Miklós Mézes, István Karádi, and Attila Molvarec
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 2

Comments (0)

Please log in or register to comment.
Log in