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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 47, Issue 4


Analytical precision of the Urolizer® for the determination of the BONN-Risk-Index (BRI) for calcium oxalate urolithiasis and evaluation of the influence of 24-h urine storage at moderate temperatures on BRI

Wolfgang Berg / Robin Bechler / Norbert Laube
  • Department of Urology, University of Bonn, Bonn, Germany
  • Deutsches Harnsteinzentrum, Medizinisches Zentrum Bonn, Bonn, Germany
  • Other articles by this author:
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Published Online: 2009-02-18 | DOI: https://doi.org/10.1515/CCLM.2009.099


Background: Since its first publication in 2000, the BONN-Risk-Index (BRI) has been successfully used to determine the calcium oxalate (CaOx) crystallization risk from urine samples. To date, a BRI-measuring device, the “Urolizer®”, has been developed, operating automatically and requiring only a minimum of preparation. Two major objectives were pursued: determination of Urolizer® precision, and determination of the influence of 24-h urine storage at moderate temperatures on BRI.

Methods: 24-h urine samples from 52 CaOx stone-formers were collected. A total of 37 urine samples were used for the investigation of Urolizer® precision by performing six independent BRI determinations in series. In total, 30 samples were taken for additional investigation of urine storability. Each sample was measured thrice: directly after collection, after 24-h storage at T=21°C, and after 24-h cooling at T=4°C. Outcomes were statistically tested for identity with regard to the immediately obtained results.

Results: Repeat measurements for evaluation of Urolizer® precision revealed statistical identity of data (p<0.05). 24-h storage of urine at both tested temperatures did not significantly affect BRI (p<0.05).

Conclusions: The pilot-run Urolizer® shows high analytical reliability. The innovative analysis device may be especially suited for urologists specializing in urolithiasis treatment. The possibility for urine storage at moderate temperatures without loss of analysis quality further demonstrates the applicability of the BRI method.

Clin Chem Lab Med 2009;47:478–82.

Keywords: calcium oxalate; crystallization risk; unpreserved urine; urine storage; urolithiasis

About the article

Corresponding author: Norbert Laube, PhD, Deutsches Harnsteinzentrum, Medizinisches Zentrum Bonn, Friedensplatz 16, 53111 Bonn, Germany Phone: +49-228-22720-176, Fax: +49-228-22720-177,

Received: 2008-09-30

Accepted: 2009-01-09

Published Online: 2009-02-18

Published in Print: 2009-04-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 4, Pages 478–482, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.099.

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