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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
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1437-4331
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Volume 47, Issue 4

Issues

Elevation of the glycoxidation product Nε-(carboxymethyl)lysine in patients presenting with acute myocardial infarction

Stefan Kralev
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Elke Zimmerer
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Martina Brueckmann
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Siegfried Lang
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Thorsten Kälsch
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Anja Rippert
  • V. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Jihong Lin
  • V. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Martin Borggrefe
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Hans-Peter Hammes
  • V. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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/ Tim Süselbeck
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
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Published Online: 2009-03-12 | DOI: https://doi.org/10.1515/CCLM.2009.100

Abstract

Background: An important role in the acceleration of vascular disease has been previously suggested for advanced glycation end products. Nε-(carboxymethyl)lysine (CML) is an advanced glycation end product formed on protein by combined non-enzymatic glycation and glycoxidation reactions. CML reacts with the receptor of advanced glycation end products inducing impairment of endothelium dependent relaxation and is a marker of oxidative stress.

Methods: A total of 40 patients with acute myocardial infarction (17 patients with ST-elevation myocardial infarction, 23 patients with non-ST-elevation myocardial infarction) and 40 patients with stable coronary artery disease were included consecutively in this study. During coronary angiography, peripheral venous blood sample was taken for measuring CML.

Results: Serum levels of CML were significantly increased in patients with acute myocardial infarction [17.9±10.7 vs. 6.6±3.1 arbitrary units (AU)/mg protein, p<0.001]. A cut-off value of CML>9.5 AU/mg protein was associated with an odds ratio of acute myocardial infarction of 39.7 [95% confidence interval (CI): 11.1–142, p<0.001], a sensitivity of 0.85 (95% CI: 0.70–0.94) and a specificity of 0.88 (95% CI: 0.73–0.96).

Conclusions: CML levels are significantly elevated in patients presenting with acute myocardial infarction. These results suggest the involvement of endothelial dysfunction (through receptor interaction) and oxidative stress in acute myocardial infarction.

Clin Chem Lab Med 2009;47:446–51.

Keywords: advanced glycation end products; endothelial dysfunction; myocardial infarction; Nε-(carboxymethyl)lysine

About the article

Corresponding author: Stefan Kralev, MD, I. Department of Medicine, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany Phone: +49-621-3832512, Fax: +49-621-3832012,


Received: 2008-09-30

Accepted: 2009-01-09

Published Online: 2009-03-12

Published in Print: 2009-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 4, Pages 446–451, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.100.

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