Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

Online
ISSN
1437-4331
See all formats and pricing
Volume 47, Issue 4 (Apr 2009)

Issues

Elevation of the glycoxidation product Nε-(carboxymethyl)lysine in patients presenting with acute myocardial infarction

Stefan Kralev
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Elke Zimmerer
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Martina Brueckmann
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Siegfried Lang
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Thorsten Kälsch
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Anja Rippert
  • V. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Jihong Lin
  • V. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Martin Borggrefe
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Hans-Peter Hammes
  • V. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
/ Tim Süselbeck
  • I. Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
Published Online: 2009-03-12 | DOI: https://doi.org/10.1515/CCLM.2009.100

Abstract

Background: An important role in the acceleration of vascular disease has been previously suggested for advanced glycation end products. Nε-(carboxymethyl)lysine (CML) is an advanced glycation end product formed on protein by combined non-enzymatic glycation and glycoxidation reactions. CML reacts with the receptor of advanced glycation end products inducing impairment of endothelium dependent relaxation and is a marker of oxidative stress.

Methods: A total of 40 patients with acute myocardial infarction (17 patients with ST-elevation myocardial infarction, 23 patients with non-ST-elevation myocardial infarction) and 40 patients with stable coronary artery disease were included consecutively in this study. During coronary angiography, peripheral venous blood sample was taken for measuring CML.

Results: Serum levels of CML were significantly increased in patients with acute myocardial infarction [17.9±10.7 vs. 6.6±3.1 arbitrary units (AU)/mg protein, p<0.001]. A cut-off value of CML>9.5 AU/mg protein was associated with an odds ratio of acute myocardial infarction of 39.7 [95% confidence interval (CI): 11.1–142, p<0.001], a sensitivity of 0.85 (95% CI: 0.70–0.94) and a specificity of 0.88 (95% CI: 0.73–0.96).

Conclusions: CML levels are significantly elevated in patients presenting with acute myocardial infarction. These results suggest the involvement of endothelial dysfunction (through receptor interaction) and oxidative stress in acute myocardial infarction.

Clin Chem Lab Med 2009;47:446–51.

Keywords: advanced glycation end products; endothelial dysfunction; myocardial infarction; Nε-(carboxymethyl)lysine

About the article

Corresponding author: Stefan Kralev, MD, I. Department of Medicine, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany Phone: +49-621-3832512, Fax: +49-621-3832012,


Received: 2008-09-30

Accepted: 2009-01-09

Published Online: 2009-03-12

Published in Print: 2009-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.100. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Daiva Stanislovaitienė, Dalia Žaliūnienė, Rasa Steponavičiūtė, Reda Žemaitienė, Olivija Gustienė, and Remigijus Žaliūnas
Medicina, 2016
[2]
Sergio Raposeiras-Roubín, Bruno K Rodino-Janeiro, Beatriz Paradela-Dobarro, Haidara Almansour, Lilian Grigorian-Shamagian, María V Reino-Maceiras, José M García-Acuña, José R González-Juanatey, and Ezequiel Álvarez
Biomarkers in Medicine, 2015, Volume 9, Number 3, Page 209
[3]
Liqing Kuang, Zhiqiang Jing, Jing Wang, Liyuan Ma, Xiaoqiang Liu, and Jin Yang
Journal of Pharmaceutical and Biomedical Analysis, 2014, Volume 90, Page 1
[4]
Morten A. Karsdal, Mette J. Nielsen, Jannie M. Sand, Kim Henriksen, Federica Genovese, Anne-Christine Bay-Jensen, Victoria Smith, Joanne I. Adamkewicz, Claus Christiansen, and Diana J. Leeming
ASSAY and Drug Development Technologies, 2013, Volume 11, Number 2, Page 70
[5]
Morten Asser Karsdal, Kim Henriksen, Diana Julie Leeming, Thasia Woodworth, Efstathios Vassiliadis, and Anne-Christine Bay-Jensen
Clinical Biochemistry, 2010, Volume 43, Number 10-11, Page 793
[6]
D. J. Leeming, A. C. Bay-Jensen, E. Vassiliadis, M. R. Larsen, K. Henriksen, and M. A. Karsdal
Biomarkers, 2011, Volume 16, Number 3, Page 193

Comments (0)

Please log in or register to comment.
Log in