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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 47, Issue 4

Issues

Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome

Ying-Hock Teng
  • Institute of Medicine, Chung Shan Medical University; Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hsiu-Ting Tsai / Yih-Shou Hsieh / Yi-Chen Chen / Chiao-Wen Lin / Meng-Chih Lee / Long-Yau Lin
  • Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Shun-Fa Yang
  • Institute of Medicine, Chung Shan Medical University; Department of Medical Research; Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar

Abstract

Background: The aim of this study was to evaluate the erythrocyte carbonic anhydrase (CA) activity in patients with hyperventilation syndrome.

Methods: A total of 71 patients with hyperventilation syndrome and 60 controls were recruited in this study for measurement of the erythrocyte CA activity. CA activity was analyzed from erythrocyte using CA esterase activity analysis.

Results: The erythrocyte CA activity was significantly elevated in the patients with hyperventilation syndrome compared to controls (31.07±1.37 U/g Hb vs. 24.67±0.99 U/g Hb, p=0.003). The standardized β value and significant R2 value of total CA activity for prediction of hyperventilation was 0.155 (p=0.016) and 0.024, respectively. Moreover, a significant negative correlation was found between total CA activity and partial pressure of carbon dioxide (PaCO2) (r=−0.185, p=0.03, n=131). Furthermore, the adjusted odds ratios for patients with hyperventilation were 11.6 (95% CI: 4.8–27.9) and 51.0 (95% CI: 5.8–445.2) for individuals with either PaCO2≤28.1 mm Hg or CA activity ≥29.71 U/g hemoglobin (Hb), and for individuals with both PaCO2≤28.1 mm Hg and CA activity ≥29.71 U/g Hb, respectively, compared to individuals with both PaCO2>28.1 mm Hg and CA activity <29.71 U/g Hb.

Conclusions: Erythrocyte CA activity was significantly elevated in patients with hyperventilation. Detection of erythrocyte CA activity may provide a potential explanatory parameter for the prediction of hyperventilation syndrome.

Clin Chem Lab Med 2009;47:441–5.

Keywords: erythrocyte carbonic anhydrase activity; hyperventilation syndrome

About the article

Corresponding authors: Shun-Fa Yang, PhD and Long-Yau Lin, MD, PhD, Institute of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo N. Road, Taichung, Taiwan, ROC Phone: +886-4-24739595#34253, Fax: +886-4-24723229, (S.-F. Yang), (L.-Y. Lin)


Received: 2008-11-30

Accepted: 2009-01-09

Published in Print: 2009-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 4, Pages 441–445, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.102.

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