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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 47, Issue 4

Issues

Novel serum paraoxonase activity assays are associated with coronary artery disease

Nicola Martinelli / Domenico Girelli / Oliviero Olivieri / Patrizia Guarini / Antonella Bassi / Elisabetta Trabetti
  • Section of Biology and Genetics, Department of Mother and Child and Biology – Genetics, University of Verona, Verona, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Simonetta Friso / Francesca Pizzolo / Claudia Bozzini / Ilaria Tenuti / Laura Annarumma / Renzo Schiavon / Pier Franco Pignatti
  • Section of Biology and Genetics, Department of Mother and Child and Biology – Genetics, University of Verona, Verona, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Roberto Corrocher
Published Online: 2009-03-11 | DOI: https://doi.org/10.1515/CCLM.2009.108

Abstract

Background: Serum paraoxonase (PON1) exerts antiatherogenic effects. Novel PON1 enzymatic tests have been recently developed: 5-thiobutyl butyrolactone (TBBL) estimates PON1 lactonase activity, whereas 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) is considered a surrogate marker of PON1 concentration. The TBBL to DEPCyMC ratio provides the normalized lactonase activity (NLA), which may reflect the degree of PON1 lactonase catalytic stimulation. The aim of this study was to evaluate for the first time TBBLase and DEPCyMCase activity in patients with coronary artery disease (CAD).

Methods: An angiography-based case-control study was conducted, including 300 sex- and age-matched subjects [100 CAD-free, 100 CAD without myocardial infarction (MI) and 100 CAD with MI].

Results: A low DEPCyMCase activity (lowest vs. highest tertile: OR 2.96, 95% CI 1.18–7.43) and a high NLA (highest vs. lowest tertile: OR 3.25, 95% CI 1.28–8.26) were both associated with CAD, independent of classical atherosclerosis risk factors, lipid-lowering therapy and PON1 genotype. Total TBBLase activity was, however, not different in CAD compared to CAD-free subjects.

Conclusions: Novel PON1 activity assays may be associated with CAD. In this study, CAD patients had low DEPCyMCase activity, a possible marker of low PON1 concentration, but showed a high stimulation of PON1 lactonase activity.

Clin Chem Lab Med 2009;47:432–40.

Keywords: coronary artery disease; DEPCyMCase activity; serum paraoxonase; TBBLase activity

About the article

Corresponding author: Nicola Martinelli, MD, Department of Clinical and Experimental Medicine, University of Verona, Policlinico G.B. Rossi, 37134 Verona, Italy Phone: +39-045-8074401, Fax: +39-045-8027473,


Received: 2008-10-08

Accepted: 2009-01-17

Published Online: 2009-03-11

Published in Print: 2009-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 4, Pages 432–440, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.108.

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