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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 47, Issue 5

Issues

Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry

Magdalena Ligor
  • Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Toruń, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tomasz Ligor
  • Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Toruń, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Amel Bajtarevic
  • Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Clemens Ager
  • Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Martin Pienz
  • Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Martin Klieber
  • Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hubert Denz
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Landeskrankenhaus Natters, Natters, Austria
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  • De Gruyter OnlineGoogle Scholar
/ Michael Fiegl
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Landeskrankenhaus Natters, Natters, Austria
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  • De Gruyter OnlineGoogle Scholar
/ Wolfgang Hilbe / Wolfgang Weiss / Peter Lukas / Herbert Jamnig / Martin Hackl / Boguslaw Buszewski
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Toruń, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wolfram Miekisch
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Department of Anaesthesiology and Intensive Care, University of Rostock, Rostock, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jochen Schubert
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Department of Anaesthesiology and Intensive Care, University of Rostock, Rostock, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Anton Amann
  • Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
  • Breath Research Unit of the Austrian Academy of Sciences, Dornbirn
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar

Abstract

Background: Analysis of exhaled breath is a promising diagnostic method. Sampling of exhaled breath is non-invasive and can be performed as often as considered desirable. There are indications that the concentration and presence of certain of volatile compounds in exhaled breath of lung cancer patients is different from concentrations in healthy volunteers. This might lead to a future diagnostic test for lung cancer.

Methods: Exhaled breath samples from 65 patients with different stages of lung cancer and undergoing different treatment regimes were analysed. Mixed expiratory and indoor air samples were collected. Solid phase microextraction (SPME) with carboxen/polydimethylsiloxane (CAR/PDMS) sorbent was applied. Compounds were analysed by means of gas chromatography (GC) and mass spectrometry (MS).

Results: The method we used allowed identification with the spectral library of 103 compounds showing at least 15% higher concentration in exhaled breath than in inhaled air. Among those 103 compounds, 84 were confirmed by determination of the retention time using standards based on the respective pure compound. Approximately, one third of the compounds detected were hydrocarbons. We found aromatic hydrocarbons, alcohols, aldehydes, ketones, esters, ethers, sulfur compounds, nitrogen-containing compounds and halogenated compounds. Acetonitrile and benzene were two of 10 compounds which correlated with smoking behaviour. A comparison of results from cancer patients with those of 31 healthy volunteers revealed differences in the concentration and presence of certain compounds. The sensitivity for detection of lung cancer patients based on eight different compounds not seen in exhaled breath of healthy volunteers was 51% and the specificity was 100%. These eight potential markers for detection of lung cancer are 1-propanol, 2-butanone, 3-butyn-2-ol, benzaldehyde, 2-methyl-pentane, 3-methyl-pentane, n-pentane and n-hexane.

Conclusions: SPME is a relatively insensitive method and compounds not observed in exhaled breath may be present at a concentration lower than LOD. The main achievement of the present work is the validated identification of compounds observed in exhaled breath of lung cancer patients. This identification is indispensible for future work on the biochemical sources of these compounds and their metabolic pathways.

Clin Chem Lab Med 2009;47:550–60.

Keywords: breath analysis; gas chromatography mass spectrometry (GC/MS); lung cancer; volatile organic compounds (VOCS)

About the article

Corresponding author: Anton Amann, Univ.-Clinic for Anesthesia, Anichstr 35, 6020 Innsbruck, Austria ,


Received: 2009-01-21

Accepted: 2009-03-02

Published in Print: 2009-05-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 5, Pages 550–560, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.133.

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