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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

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Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 47, Issue 6 (Jun 2009)

Issues

Approaching clinical proteomics: current state and future fields of application in fluid proteomics

Rolf Apweiler
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
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/ Charalampos Aslanidis
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
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/ Thomas Deufel
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
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/ Andreas Gerstner
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Department of Otorhinolaryngology/Surgery, University of Bonn, Bonn, Germany
  • DGfZ – Deutsche Gesellschaft für Zytometrie (www.dgfz.org)
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/ Jens Hansen
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
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/ Dennis Hochstrasser
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Department of Pathology/Clinical Chemistry, University of Geneva, Geneva, Switzerland
  • SSCC – Schweizerische Gesellschaft für Klinische Chemie (www.sscc.ch)
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/ Roland Kellner
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Merck, Darmstadt, Germany
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
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/ Markus Kubicek
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
  • ÖGLMKC – Österreichische Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (www.oeglmkc.at)
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/ Friedrich Lottspeich
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Max-Planck-Institute for Biochemistry, Martinsried/Munich, Germany
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
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/ Edmund Maser / Hans-Werner Mewes
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute for Bioinformatics, GSF, Neuherberg, Germany
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/ Helmut E. Meyer
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Medical Proteomics Center, University of Bochum, Bochum, Germany
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
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/ Stefan Müllner
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Protagen, Dortmund, Germany
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
  • Danubian Biobank Consortium (www.danubianbiobank.de)
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/ Wolfgang Mutter
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • PROFOS, Regensburg, Germany
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
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/ Michael Neumaier
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute for Clinical Chemistry, University Hospital Mannheim, Mannheim, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
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/ Peter Nollau
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute for Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
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/ Hans G. Nothwang
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Department of Animal Physiology, Technical University Kaiserslautern, Kaiserslautern, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
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/ Fredrik Ponten
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute for Genetics and Pathology, University of Uppsala, Uppsala, Sweden
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/ Andreas Radbruch
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • German Rheumatism Research Center Berlin, Berlin, Germany
  • DGfZ – Deutsche Gesellschaft für Zytometrie (www.dgfz.org)
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/ Knut Reinert
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Department of Mathematics and Computer Science, University of Berlin, Berlin, Germany
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/ Gregor Rothe
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Laboratory Center Bremen, Bremen, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
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/ Hannes Stockinger
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Department of Molecular Immunology, University of Vienna, Vienna, Austria
  • DGfZ – Deutsche Gesellschaft für Zytometrie (www.dgfz.org)
  • Danubian Biobank Consortium (www.danubianbiobank.de)
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/ Attila Tarnok
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Department of Pediatric Cardiology, University of Leipzig, Leipzig, Germany
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/ Mike J. Taussig
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Technology Research Group, The Babraham Institute Cambridge, Cambridge, UK
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/ Andreas Thiel
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • German Rheumatism Research Center Berlin, Berlin, Germany
  • DGfZ – Deutsche Gesellschaft für Zytometrie (www.dgfz.org)
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/ Joachim Thiery
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
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/ Marius Ueffing
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute of Human Genetics, GSF Neuherberg, Neuherberg, Germany
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
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/ Günther Valet
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Max-Planck-Institute for Biochemistry, Martinsried/Munich, Germany
  • DGfZ – Deutsche Gesellschaft für Zytometrie (www.dgfz.org)
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/ Joel Vandekerckhove
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Department of Medical Protein Research, University of Gent, Gent, Belgium
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/ Wiltrud Verhuven
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Waters, Eschborn, Germany
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/ Christoph Wagener
  • European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute for Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
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  • De Gruyter OnlineGoogle Scholar
/ Oswald Wagner
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
  • ÖGLMKC – Österreichische Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (www.oeglmkc.at)
  • Danubian Biobank Consortium (www.danubianbiobank.de)
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/ Gerd Schmitz
  • Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
  • Institute for Clinical Chemistry and Laboratory Diagnostics, University of Jena, Jena, Germany
  • Consensus document of the DGKL – Deutsche Vereinte Gesellschaft für Klinische Chemie und Laboratorioumsmedizin (www.dgkl.de)
  • DGPF – Deutsche Gesellschaft für Proteomforschung (www.dgpf.org)
  • Danubian Biobank Consortium (www.danubianbiobank.de)
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar

Abstract

The field of clinical proteomics offers opportunities to identify new disease biomarkers in body fluids, cells and tissues. These biomarkers can be used in clinical applications for diagnosis, stratification of patients for specific treatment, or therapy monitoring. New protein array formats and improved spectrometry technologies have brought these analyses to a level with potential for use in clinical diagnostics. The nature of the human body fluid proteome with its large dynamic range of protein concentrations presents problems with quantitation. The extreme complexity of the proteome in body fluids presents enormous challenges and requires the establishment of standard operating procedures for handling of specimens, increasing sensitivity for detection and bioinformatical tools for distribution of proteomic data into the public domain. From studies of in vitro diagnostics, especially in clinical chemistry, it is evident that most errors occur in the preanalytical phase and during implementation of the diagnostic strategy. This is also true for clinical proteomics, and especially for fluid proteomics because of the multiple pretreatment processes. These processes include depletion of high-abundance proteins from plasma or enrichment processes for urine where biological variation or differences in proteolytic activities in the sample along with preanalytical variables such as inter- and intra-assay variability will likely influence the results of proteomics studies. However, before proteomic analysis can be introduced at a broader level into the clinical setting, standardization of the preanalytical phase including patient preparation, sample collection, sample preparation, sample storage, measurement and data analysis needs to be improved. In this review, we discuss the recent technological advances and applications that fulfil the criteria for clinical proteomics, with the focus on fluid proteomics. These advances relate to preanalytical factors, analytical standardization and quality-control measures required for effective implementation into routine laboratory testing in order to generate clinically useful information. With new disease biomarker candidates, it will be crucial to design and perform clinical studies that can identify novel diagnostic strategies based on these techniques, and to validate their impact on clinical decision-making.

Clin Chem Lab Med 2009;47:724–44.

Keywords: cerebrospinal fluid (CSF); clinical proteomics; fluid proteomics; mass spectrometry (MS); matrix assisted laser desorption/ionization (MALDI); preanalytical effects; standard operating procedures (SOP); surface-enhanced laser desorption/ionization (SELDI)

About the article

Corresponding author: Prof. Dr. med. Gerd Schmitz, Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany Phone: +49-941-944-6201, Fax: +49-941-944-6202,


Received: 2008-10-14

Accepted: 2009-05-12

Published in Print: 2009-06-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.167.

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©2009 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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