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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 47, Issue 7


Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis

Irena Dujmovic / Tatjana Pekmezovic / Radmila Obrenovic / Aleksandra Nikolić / Mihailo Spasic / Marija Mostarica Stojkovic / Jelena Drulovic
Published Online: 2009-06-04 | DOI: https://doi.org/10.1515/CCLM.2009.192


Background: Peroxynitrite was hypothesized to be involved in the pathogenesis of multiple sclerosis (MS) through its various neurotoxic effects. Uric acid (UA) was shown to be a strong peroxynitrite scavenger.

Methods: We analyzed cerebrospinal fluid (CSF) and serum UA concentrations in 30 MS patients and 20 controls with non-inflammatory neurological diseases (NIND) and correlated these findings with demographic and clinical characteristics of MS patients. Disease activity was assessed by brain magnetic resonance imaging (MRI) and the CSF/serum albumin quotient as an indicator of the state of blood-brain-barrier (BBB).

Results: Serum UA concentrations were found to be significantly lower in MS patients compared with controls (p=0.019). CSF UA concentrations were lower in MS patients as compared to controls, as well as in patients with active MS (clinical and/or MRI activity) in comparison to patients with inactive MS or controls, but these differences were not statistically significant. Significant correlation was found between CSF and serum UA concentrations (p=0.016) in MS patients, but not in controls; and between CSF UA concentrations and the CSF/serum albumin quotient in MS patients (p=0.043), but not in controls.

Conclusions: Our results support the significance of UA in the pathogenesis of MS. Decreased serum UA concentrations in MS patients might be due to both intrinsically reduced antioxidant capacity and increased UA consumption in MS. CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS).

Clin Chem Lab Med 2009;47:848–53.

Keywords: cerebrospinal fluid (CSF); disease activity; multiple sclerosis (MS); serum; uric acid (UA)

About the article

Corresponding author: Irena Dujmovic, Institute of Neurology, Clinical Center of Serbia, Dr Subotica 6, Belgrade 11 000, Serbia Phone: +381 63 84 48 600, Fax: +381 11 2685 662,

Received: 2009-03-21

Accepted: 2009-04-21

Published Online: 2009-06-04

Published in Print: 2009-07-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 7, Pages 848–853, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.192.

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