Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 47, Issue 7


Gender difference and determinants of C-reactive protein level in Korean adults

Yong-Jae Lee / Jung-Hyun Lee
  • Department of Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Youn-Ho Shin / Jong-Koo Kim / Hye-Ree Lee / Duk-Chul Lee


Background: C-reactive protein (CRP) has emerged as an important predictor for cardiovascular disease (CVD). To facilitate clinical and public health interventions, CRP thresholds have been defined as follows: low-risk (<1.0 mg/L), average-risk (1.0–3.0 mg/L), and high-risk (>3.0 mg/L). However, these cut-off thresholds are based on distributions in Western populations, and do not distinguish between men and women.

Methods: We examined CRP distribution, gender difference, and determinants of CRP concentrations ranging from 0.02 mg/L to 10.0 mg/L, in 4923 Korean adults (2248 men; 2675 women) who received health checkups at Gangnam Severance Hospital from March 2006 to May 2007.

Results: The distribution of CRP was highly skewed toward lower concentrations. CRP was higher in men than women, and the cut-off thresholds for the high-risk tertile of CRP concentrations corresponded to 1.01 mg/L in men and 0.62 mg/L in women, based on the current study population. Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, γ-glutamyltransferase, and uric acid were independently associated with CRP concentrations.

Conclusions: CRP distribution and gender difference in Korean adults were found to be different from previous Western studies, although similar risk factors influence CRP concentrations. Our results suggest that ethnicity and gender specific cut-off thresholds for CRP concentrations should be taken into consideration in CVD risk assessment.

Clin Chem Lab Med 2009;47:863–9.

Keywords: cardiovascular disease (CVD); C-reactive protein (CRP); gender difference

About the article

Corresponding author: Duk-Chul Lee, MD, PhD, Department of Family Medicine, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul, Korea Phone: +82-2-2228-2331, Fax: +82-2-362-2473,

Received: 2009-01-24

Accepted: 2009-04-20

Published in Print: 2009-07-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 47, Issue 7, Pages 863–869, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.196.

Export Citation

©2009 by Walter de Gruyter Berlin New York.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Giovanni Barosi, Margherita Massa, Rita Campanelli, Gabriela Fois, Paolo Catarsi, Gianluca Viarengo, Laura Villani, Valentina Poletto, Tiziana Bosoni, Umberto Magrini, Robert P. Gale, and Vittorio Rosti
Leukemia Research, 2017, Volume 60, Page 18
C. M. Khoo, S. Sairazi, S. Taslim, D. Gardner, Y. Wu, J. Lee, R. M. van Dam, and E. Shyong Tai
Diabetes Care, 2011, Volume 34, Number 5, Page 1120
Laura Billiet, Sarah Doaty, James D. Katz, and Manuel T. Velasquez
ISRN Rheumatology, 2014, Volume 2014, Page 1
Sara Ahmadi-Abhari, Robert N. Luben, Nicholas J. Wareham, and Kay-Tee Khaw
European Journal of Clinical Investigation, 2013, Volume 43, Number 9, Page 899
J. Choi, L. Joseph, and L. Pilote
Obesity Reviews, 2013, Volume 14, Number 3, Page 232
R.K.C. Kann, J.M. Seddon, J. Henning, and J. Meers
Research in Veterinary Science, 2012, Volume 93, Number 2, Page 649
Dong-Hyuk Jung, Yong-Jae Lee, Hong-Yup Ahn, Jae-Yong Shim, Jung-Hyun Lee, and Hye-Ree Lee
Maturitas, 2010, Volume 66, Number 1, Page 83
C M Khoo, M Tan, Y Wu, C H Wai, T Subramaniam, J Lee, and E S Tai
Nutrition and Diabetes, 2011, Volume 1, Number 5, Page e8
H Yatsuya, R W Jeffery, S L Langer, N Mitchell, A P Flood, E M Welsh, M A Jaeb, P S Laqua, M Crowell, and R L Levy
International Journal of Obesity, 2011, Volume 35, Number 5, Page 684
Yong-Jae Lee, Hye-Ree Lee, Jung-Hyun Lee, Youn-Ho Shin, and Jae-Yong Shim
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 2

Comments (0)

Please log in or register to comment.
Log in