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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese

Wen Hui Peng1, 2 / Lin Lu1, 2 / Qi Zhang1 / Rui Yan Zhang1 / Ling Jie Wang2 / Xiao Xiang Yan2 / Qiu Jing Chen2 / Wei Feng Shen1, 2

1Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China

2Institute of Cardiovascular Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China

Corresponding author: Wei Feng Shen, PhD, MD, Department of Cardiology, Rui Jin Hospital, 197 Rui Jin Road II, Shanghai 200025, P.R. China Phone: +86-21-64370045, Fax: +86-21-64457177,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 8, Pages 917–922, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.215, June 2009

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Background: rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese.

Methods: rs1333049 polymorphism was genotyped in 520 patients with a first acute MI and in 560 controls. The number of angiographically documented diseased coronary arteries (luminal diameter stenosis ≥50%), echocardiographic left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACE) during follow-up (mean, 29±15 months) were recorded.

Results: Patients with MI had higher frequencies of the CC genotype (30.0% vs. 20.7%) or C allele (55.5% vs. 46.2%) compared with controls (all p<0.01). rs1333049 polymorphism was strongly associated with MI [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.22–1.79] after adjusting for traditional risk factors. Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.

Conclusions: This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese.

Clin Chem Lab Med 2009;47:917–22.

Keywords: coronary artery disease (CAD); myocardial infarction (MI); outcome; 9p21; polymorphism

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