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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

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Source Normalized Impact per Paper (SNIP) 2016: 1.112

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Volume 47, Issue 8 (Aug 2009)


Neutrophil CD64: a diagnostic marker for infection and sepsis

Johannes J.M.L. Hoffmann
  • Abbott Diagnostics Division, Abbott GmbH & Co. KG, Wiesbaden, Germany


Neutrophilic granulocytes express Fcγ receptor (FcγR) [cluster of differentiation 64 (CD64) antigen] only when they are activated. Neutrophil CD64, demonstrated using flow cytometry, can be used as a diagnostic marker of infection and sepsis. Neutrophil CD64 is superior to C-reactive protein and hematological determinations for detecting systemic infection or sepsis, since it combines high sensitivity (90% or more) with high specificity (90%–100%) in both adults and children. In addition, the test performs well in distinguishing infection from flares in autoimmune inflammatory diseases and has somewhat more limited utility for differentiating bacterial from viral infection. This review summarizes the available literature regarding CD64 as a marker of infection, and outlines future clinical studies for confirming the diagnostic performance of this promising marker.

Clin Chem Lab Med 2009;47:903–16.

Keywords: cluster of differentiation 64 (CD64); diagnostic tests; Fcγ receptor (FcγR); infection; neutrophils; sensitivity; sepsis; specificity

About the article

Corresponding author: Dr. J.J.M.L. Hoffmann, Abbott Diagnostics Division, Abbott GmbH and Co. KG, Max-Planck-Ring 2, 65205 Wiesbaden-Delkenheim, Germany Phone: + 49 6122 581445,

Received: 2009-03-29

Accepted: 2009-05-25

Published in Print: 2009-08-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2009.224.

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©2009 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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