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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Platelet physiology and antiplatelet agents

Tim Thijs1 / Benedicte P. Nuyttens1 / 1 / Katleen Broos1

1Laboratory for Thrombosis Research, KU Leuven campus Kortrijk, Kortrijk, Belgium

Corresponding author: Hans Deckmyn, Laboratory for Thrombosis Research, KU Leuven campus Kortrijk, E. Sabbelaan 53, 8500 Kortrijk, Belgium Phone: +32 56 246422, Fax: +32 56 246997

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Pages S3–S13, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2010.363, November 2010

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Apart from the central beneficial role platelets play in hemostasis, they are also involved in atherothrombotic diseases. Here, we review the current knowledge of platelet intracellular signal transduction pathways involved in platelet adhesion, activation, amplification of the activation signal and aggregation, as well as pathways limiting platelet aggregation. A thorough understanding of these pathways allows explanation of the mechanism of action of existing antiplatelet agents, but also helps to identify targets for novel drug development.

Clin Chem Lab Med 2010;48:S3–13.

Keywords: antiplatelet agents; platelet activation; platelet adhesion; platelet aggregation; platelet inhibition

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