Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue

Issues

30,00 € / $42.00 / £23.00

Get Access to Full Text

Platelet physiology and antiplatelet agents

Tim Thijs1 / Benedicte P. Nuyttens1 / 1 / Katleen Broos1

1Laboratory for Thrombosis Research, KU Leuven campus Kortrijk, Kortrijk, Belgium

Corresponding author: Hans Deckmyn, Laboratory for Thrombosis Research, KU Leuven campus Kortrijk, E. Sabbelaan 53, 8500 Kortrijk, Belgium Phone: +32 56 246422, Fax: +32 56 246997

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Pages S3–S13, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2010.363, November 2010

Publication History

Received:
2010-06-07
Accepted:
2010-09-05
Published Online:
2010-11-06

Abstract

Apart from the central beneficial role platelets play in hemostasis, they are also involved in atherothrombotic diseases. Here, we review the current knowledge of platelet intracellular signal transduction pathways involved in platelet adhesion, activation, amplification of the activation signal and aggregation, as well as pathways limiting platelet aggregation. A thorough understanding of these pathways allows explanation of the mechanism of action of existing antiplatelet agents, but also helps to identify targets for novel drug development.

Clin Chem Lab Med 2010;48:S3–13.

Keywords: antiplatelet agents; platelet activation; platelet adhesion; platelet aggregation; platelet inhibition

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
G Ramalingam, N Jones, and M Besser
BJA Education, 2016, Volume 16, Number 4, Page 134
[2]
G Ramalingam, N Jones, and M Besser
BJA Education, 2015, Page mkv027
[3]
Bo Wiinberg, Lisbeth R. Jessen, Inge Tarnow, and Annemarie T. Kristensen
Journal of Veterinary Emergency and Critical Care, 2012, Volume 22, Number 1, Page 42

Comments (0)

Please log in or register to comment.