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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

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Pediatric thrombosis

1University Children's Hospital, University Medical Centre, Ljubljana, Slovenia

Corresponding author: Alenka Trampus Bakija, University Children's Hospital, University Medical Centre, Ljubljana, Bohoričeva 20, 1000 Ljubljana, Slovenia Phone: +386 1 522 47 75, Fax: +386 1 522 39 57

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Pages S97–S104, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2010.364, November 2010

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Thrombotic risk factors and thrombosis in children has been receiving increased attention. True idiopathic thrombosis is extremely rare in children. Most patients have a significant underlying medical condition and the presence of a central catheter is the most important risk factor. Children are more likely than adults to have one or more significant genetic abnormality or coagulation deficiency. This review discusses problems concerning the heterogeneity of thrombotic states in children and highlights the importance of understanding the concept of developmental hemostasis. Issues regarding step-wise test selection and the interpretation of results are addressed, as well as basic monitoring of anticoagulant drug effects.

Clin Chem Lab Med 2010;48:S97–104.

Keywords: hemostasis; interpretation of results; laboratory tests; pediatric thrombosis; screening; thrombophilia

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