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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 48, Issue 1 (Jan 2010)

Issues

The role of anti-core antibody response in the detection of occult hepatitis B virus infection

Simona Urbani
  • Unità Operativa di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
/ Francesco Fagnoni
  • Unità Operativa di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
/ Gabriele Missale
  • Unità Operativa di Malattie Infettive ed Epatologia, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
/ Massimo Franchini
  • Unità Operativa di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
Published Online: 2009-11-18 | DOI: https://doi.org/10.1515/CCLM.2010.002

Abstract

Occult hepatitis B virus (HBV) infection is characterized by the presence of HBV DNA in serum and/or in the liver of patients negative for hepatitis B surface antigen (HBsAg). Occult infection may impact in several different clinical contexts including the risk of HBV transmission with transfusion or transplantation, and endogenous viral reactivation. The gold standard test for detection of occult infection is the amplification of HBV DNA. However, the serological assay for the long-lasting antibody response to the highly immunogenic HBV core antigen (anti-HBc) represents a qualified candidate as a surrogate for DNA amplification, or for increasing overall sensitivity when assessing the risk of occult hepatitis in peripheral blood. The risk of occult hepatitis associated with anti-HBc seropositivity has been demonstrated extensively, and the presence of antibody response to HBc can be considered a sentinel marker of occult HBV infection.

Clin Chem Lab Med 2010;48:23–9.

Keywords: anti-core antibody response; HBV core (HBc); hepatitis B virus (HBV); occult hepatitis B infection; reactivation; transfusion; transplantation

About the article

Corresponding author: Dr. Simona Urbani, Unità Operativa di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43123 Parma, Italy Phone: +39-0521-704816, Fax: +39-0521-703197,


Received: 2009-07-22

Accepted: 2009-09-01

Published Online: 2009-11-18

Published in Print: 2010-01-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.002.

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©2010 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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