Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

The role of anti-core antibody response in the detection of occult hepatitis B virus infection

Simona Urbani1 / Francesco Fagnoni1 / Gabriele Missale2 / Massimo Franchini1

1Unità Operativa di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

2Unità Operativa di Malattie Infettive ed Epatologia, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

Corresponding author: Dr. Simona Urbani, Unità Operativa di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43123 Parma, Italy Phone: +39-0521-704816, Fax: +39-0521-703197,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Issue 1, Pages 23–29, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.002, November 2009

Publication History

Published Online:


Occult hepatitis B virus (HBV) infection is characterized by the presence of HBV DNA in serum and/or in the liver of patients negative for hepatitis B surface antigen (HBsAg). Occult infection may impact in several different clinical contexts including the risk of HBV transmission with transfusion or transplantation, and endogenous viral reactivation. The gold standard test for detection of occult infection is the amplification of HBV DNA. However, the serological assay for the long-lasting antibody response to the highly immunogenic HBV core antigen (anti-HBc) represents a qualified candidate as a surrogate for DNA amplification, or for increasing overall sensitivity when assessing the risk of occult hepatitis in peripheral blood. The risk of occult hepatitis associated with anti-HBc seropositivity has been demonstrated extensively, and the presence of antibody response to HBc can be considered a sentinel marker of occult HBV infection.

Clin Chem Lab Med 2010;48:23–9.

Keywords: anti-core antibody response; HBV core (HBc); hepatitis B virus (HBV); occult hepatitis B infection; reactivation; transfusion; transplantation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Amitis Ramezani, Mohammad Reza Aghasadeghi, Farrokhlagha Ahmadi, Effat Razeghi, Ali Eslamifar, Mohammad Banifazl, Masoomeh Sofian, Golnaz Bahramali, Soheila Hekmat, and Arezoo Aghakhani
Nephro-Urology Monthly, 2014, Volume 7, Number 1
Tamer A. Elbedewy, Hossam Eldin A. Elashtokhy, Enaam S. Rabee, and Gamal E. Kheder
Journal of the Egyptian National Cancer Institute, 2015, Volume 27, Number 1, Page 11
Wei Jia, Liu-Wei Song, Yu-Qing Fang, Xiao-Feng Wu, Dan-Yang Liu, Chun Xu, Xiao-Mei Wang, Wen Wang, Dong-Xia Lv, Jun Li, Yong-Qiong Deng, Yan Wang, Na Huo, Min Yu, Hong-Li Xi, Dan Liu, Yi-Xing Zhou, Gui-Qiang Wang, Ning-Shao Xia, and Ming-Xiang Zhang
Medicine, 2014, Volume 93, Number 29, Page e322
Gamal El Din Ahmed Elsawaf, Ola Abd EL Kader Mahmoud, Sherine Mohamed Shawky, Hanan Mostafa Mostafa Mohamed, and Hafez Hezam Ahmed Alsumairy
Alexandria Journal of Medicine, 2015
So Mi Kim, Hyun Woo Kim, Ji Eun Lee, Eun Kyoung Lee, Hyun Deok Shin, and Il Han Song
Hemodialysis International, 2015, Volume 19, Number 1, Page 66
Fabio Tramuto, Carmelo Massimo Maida, Giuseppina M. E. Colomba, Paola Di Carlo, and Francesco Vitale
BioMed Research International, 2013, Volume 2013, Page 1
So-Young Kang, Myeong-Hee Kim, and Woo-In Lee
Archives of Virology, 2014, Volume 159, Number 2, Page 227
Mehdi Zobeiri
Hepatitis Research and Treatment, 2013, Volume 2013, Page 1
Naoko Tsubouchi, Hirofumi Uto, Kotaro Kumagai, Fumisato Sasaki, Shuji Kanmura, Masatsugu Numata, Akihiro Moriuchi, Makoto Oketani, Akio Ido, Katsuhiro Hayashi, Kazunori Kusumoto, Kazuya Shimoda, Sherri O. Stuver, and Hirohito Tsubouchi
Hepatology Research, 2013, Volume 43, Number 11, Page 1130
Mario Mandalà, Stefano Fagiuoli, Daniela Francisci, Raffaele Bruno, Barbara Merelli, Luisa Pasulo, Carlo Tondini, Roberto Labianca, and Fausto Roila
Critical Reviews in Oncology/Hematology, 2013, Volume 87, Number 1, Page 12
Ali Khamesipour and Reza Jafari Shakib
Transfusion and Apheresis Science, 2012, Volume 47, Number 3, Page 371
Fabio Tramuto, Carmelo M. Maida, Giuseppina M. E. Colomba, Paola Di Carlo, Giovanni Mazzola, Valentina Li Vecchi, Mario Affronti, Giuseppe Montalto, and Francesco Vitale
Journal of Immigrant and Minority Health, 2013, Volume 15, Number 4, Page 725
Fabio Tramuto, Walter Mazzucco, Carmelo Massimo Maida, Andrea Affronti, Mario Affronti, Giuseppe Montalto, and Francesco Vitale
Journal of Community Health, 2012, Volume 37, Number 3, Page 547
Donald M. Arnold, Mark A. Crowther, Ralph M. Meyer, Julie Carruthers, Julie DiTomasso, Nancy M. Heddle, Anne McLeod, and John G. Kelton
Transfusion, 2010, Volume 50, Number 12, Page 2577

Comments (0)

Please log in or register to comment.