Abstract
Background: Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients.
Methods: In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed.
Results: Serum HDL had a significant inverse correlation with a total negative syndrome score (ρ=−0.43; p=0.001).
Conclusions: The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
Clin Chem Lab Med 2010;48:95–8.
©2010 by Walter de Gruyter Berlin New York