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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
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Volume 48, Issue 1

Issues

Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia

Ganesan Venkatasubramanian
  • The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rashmi Arasappa
  • The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Naren P. Rao
  • The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rishikesh V. Behere
  • The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sunil Kalmady
  • The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bangalore N. Gangadhar
  • The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-11-25 | DOI: https://doi.org/10.1515/CCLM.2010.004

Abstract

Background: Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients.

Methods: In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed.

Results: Serum HDL had a significant inverse correlation with a total negative syndrome score (ρ=−0.43; p=0.001).

Conclusions: The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.

Clin Chem Lab Med 2010;48:95–8.

Keywords: apolipoprotein L; high-density lipoprotein; negative syndrome; schizophrenia

About the article

Corresponding author: Dr. Ganesan Venkatasubramanian, MD, The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore – 560029, Karnataka, India Phone: +91 80 26995256, Fax: +91 80 26564830,


Received: 2009-07-14

Accepted: 2009-09-16

Published Online: 2009-11-25

Published in Print: 2010-01-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 1, Pages 95–98, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.004.

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