Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 48, Issue 1

Issues

Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)

Nele Friedrich
  • Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alexander Krebs
  • Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Matthias Nauck
  • Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Henri Wallaschofski
  • Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-11-30 | DOI: https://doi.org/10.1515/CCLM.2010.009

Abstract

Background: The objective of the present study was to calculate age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) concentrations using quantile regression.

Methods: From the Study of Health in Pomerania (SHIP), 1798 men and women aged 25–85 years were recruited. Serum IGF-I and IGFBP-3 concentrations were determined using a chemiluminescent immunometric assay on an Immulite 2500® analyzer. Quantile regressions were performed to calculate the 2.5th and 97.5th percentiles.

Results: The reference ranges identified 43 (4.6%) women and 41 (4.8%) men with serum IGF-I concentrations, and 47 (5.0%) women and 42 (5.0%) men with serum IGFBP-3 concentrations outside the reference range.

Conclusions: The use of quantile regression results in accurate calculation of age- and gender-specific reference ranges for serum IGF-I and IGFBP-3.

Clin Chem Lab Med 2010;48:115–20.

Keywords: Immulite 2500; insulin-like growth factor I; insulin-like growth factor binding protein; quantile regression; references ranges; Study of Health in Pomerania (SHIP)

About the article

Corresponding author: Nele Friedrich, PhD, Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University, Ferdinand-Sauerbruch-Straße NK, 17475 Greifswald, Germany Phone: +49-3834-8619655, Fax: +49-3834-866684,


Received: 2009-06-11

Accepted: 2009-09-10

Published Online: 2009-11-30

Published in Print: 2010-01-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 1, Pages 115–120, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.009.

Export Citation

©2010 by Walter de Gruyter Berlin New York.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
TAKUDZWA A. MADZIMA, MICHAEL J. ORMSBEE, ERICA A. SCHLEICHER, ROBERT J. MOFFATT, and LYNN B. PANTON
Medicine & Science in Sports & Exercise, 2017, Volume 49, Number 7, Page 1283
[2]
Liran Franco, Frances M. K. Williams, Svetlana Trofimov, Ida Malkin, Gabriela Surdulescu, Timothy Spector, and Gregory Livshits
AGE, 2014, Volume 36, Number 3
[3]
Berrak Guven, Murat Can, Gorkem Mungan, and Serefden Acіkgoz
Scandinavian Journal of Clinical and Laboratory Investigation, 2013, Volume 73, Number 2, Page 135
[4]
Ali N. Harb, Birte Holtfreter, Nele Friedrich, Henri Wallaschofski, Matthias Nauck, and Thomas Kocher
ISRN Dentistry, 2012, Volume 2012, Page 1

Comments (0)

Please log in or register to comment.
Log in