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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism

Adriana Santi1 / Marta Maria Medeiros Frescura Duarte2 / Rafael Noal Moresco3 / Charlene Menezes2 / Margarete Dulce Bagatini2 / Maria Rosa Chitolina Schetinger2 / Vania Lucia Loro1, 2

1Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil

2Departamento de Química, Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, RS, Brazil

3Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

Corresponding author: Vania Lucia Loro, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil Phone: +55 55 32209456, Fax: +55 55 32208240,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Issue 11, Pages 1635–1639, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.309, August 2010

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Published Online:


Background: The aim of this study was to investigate the effect of hypothyroidism on lipid peroxidation and the antioxidant profile, as well as to evaluate the interaction between thyroid hormones and biomarkers of oxidative stress in patients with overt hypothyroidism. We also evaluated the influence of cholesterol concentrations on biomarkers of oxidative stress in these same patients.

Methods: Total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and vitamin E were measured in 20 subjects with overt hypothyroidism (OH) and 20 controls.

Results: TC, LDL cholesterol, triglycerides, TBARS, SOD, CAT, and vitamin E were significantly higher in the OH group. Significant correlation was observed for TSH and SOD, CAT, vitamin E and TBARS. Correlation was observed for triiodothyronine (T3) and SOD, CAT, vitamin E and TBARS. Significant correlation was also observed for free thyroxine and vitamin E and TBARS. However, correlation between T3 and CAT remained significant after controlling for TC concentrations.

Conclusions: Overt hypothyroidism is associated with an increase in oxidative stress, and hypercholesterolemia has a stronger influence on development of oxidative stress in hypothyroid conditions compared with thyroid hormones.

Clin Chem Lab Med 2010;48:1635–9.

Keywords: hypothyroidism; lipids; oxidative stress; thyroid hormones

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