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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

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1437-4331
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Volume 48, Issue 11 (Nov 2010)

Issues

Standardizing plasma protein measurements worldwide: a challenging enterprise

Giampaolo Merlini
  • Biotechnology Research Laboratories, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Department of Biochemistry, University of Pavia, Pavia, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Søren Blirup-Jensen / A. Myron Johnson
  • Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
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/ Joanna Sheldon / Ingrid Zegers
  • Institute for Reference Materials and Measurements (IRMM), Joint Research Centre, European Commission, Geel, Belgium
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Published Online: 2010-10-20 | DOI: https://doi.org/10.1515/CCLM.2010.314

Abstract

The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma Proteins of the IFCC Scientific Division to achieve worldwide comparability in plasma protein results. We focus on the production of reference materials and the methods applied throughout their production process. Particularly, the recent characterization of ERM-DA470k/IFCC and ERM-DA472/IFCC has demonstrated that it is possible to reproduce the earlier established procedures and thereby maintain standardization. Plasma protein reference materials have had a substantial impact in improving the harmonization of patient protein results that should translate into better patient care.

Clin Chem Lab Med 2010;48:1567–75.

Keywords: harmonization; plasma proteins; reference material; traceability

About the article

Corresponding author: Giampaolo Merlini, Biotechnology Research Laboratories, Fondazione IRCCS Policlinico San Matteo, Department of Biochemistry, University of Pavia, P.le Golgi, 19, 27100 Pavia, Italy Phone: +39-0382-502995, Fax: +39-0382-502990,


Published Online: 2010-10-20

Published in Print: 2010-11-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.314.

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©2010 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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