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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 48, Issue 12


Relationship of hepatic steatosis and alanine aminotransferase with coronary calcification

Dong-Hyuk Jung / Yong-Jae Lee / Hong-Yup Ahn / Jae-Yong Shim / Hye-Ree Lee
Published Online: 2010-10-20 | DOI: https://doi.org/10.1515/CCLM.2010.349


Background: It has been observed that hepatic steatosis is related to an increased risk of cardiovascular disease (CVD). Alanine aminotransferase (ALT), an indicator of the severity of hepatic steatosis is also associated with CVD. This study focused on the relationship between hepatic steatosis and ALT with coronary calcification.

Methods: We performed a cross-sectional study to examine the association between hepatic steatosis and serum ALT with coronary calcification in 1218 subjects (772 men, 446 women; ages 30–75 years). We evaluated hepatic steatosis and ALT as categorical variables, and constructed four groups (reference group; only with hepatic steatosis; only with ALT >30 U/L; with both hepatic steatosis and ALT >30 U/L), which did not overlap. Multi-detected row computed tomography (MDCT) was used to measure coronary calcium score.

Results: The adjusted ORs (95% CIs) for coronary calcification in the four groups were 1.00 (reference), 1.24 (0.68–2.26), 1.82 (0.78–4.23), and 2.12 (1.08–4.20) after adjusting for confounding variables. In addition, an increase in serum ALT activity of 10 U/L was associated with an increased risk of coronary atherosclerosis.

Conclusions: In summary, patients with both hepatic steatosis and increases in ALT are associated with coronary calcification as a marker of coronary atherosclerosis determined by MDCT. This finding suggested that subjects with both hepatic steatosis and increased ALT should be considered for further evaluation of coronary atherosclerosis.

Clin Chem Lab Med 2010;48:1829–34.

Keywords: alanine aminotransferase; coronary calcification; hepatic steatosis

About the article

Corresponding author: Hye-Ree Lee, MD, PhD, Professor, Department of Family Medicine, Yonsei University College of Medicine, 146-92 Dogok-dong, Gangnam-gu, Seoul, Korea Phone: +82 2-2019-3484, Fax: +82 2-3463-3287,

Received: 2010-02-10

Accepted: 2010-06-24

Published Online: 2010-10-20

Published in Print: 2010-12-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 12, Pages 1829–1834, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.349.

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