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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
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Volume 48, Issue 3

Issues

Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility

Yu-Chiao Yi
  • Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
  • Yu-Chiao Yi and Pai-Ta Chou contributed equally to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pai-Ta Chou
  • Dajia Lee's General Hospital, Lee's Medical Corporation, Taichung, Taiwan
  • Yu-Chiao Yi and Pai-Ta Chou contributed equally to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ling-Yun Chen / Wu-Hsien Kuo
  • Department of Medicine, Armed-Force Taichung General Hospital, General Education Center, Central Taiwan University of Science and Technology, Taichung, Taiwan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Esther Shih-Chu Ho
  • Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, School of Medicine, National Yang Ming University, Taipei, Taiwan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Chih-Ping Han
  • Institute of Medicine, Chung Shan Medical University, Clinical Research Center, Chung Shan Medical University Hospital, Taichung, Taiwan
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  • De Gruyter OnlineGoogle Scholar
/ Shun-Fa Yang
  • Institute of Medicine, Chung Shan Medical University, Clinical Research Center, Department of Medical Research, Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-02-01 | DOI: https://doi.org/10.1515/CCLM.2010.082

Abstract

Background: The goal of our study was to evaluate the influence of genetic polymorphisms of matrix metalloproteinases (MMP)-2, MMP-3 and MMP-7 on susceptibility to endometrial cancer.

Methods: In the present study, we enrolled a total of 118 patients with endometrial cancer confirmed by histopathology, and 229 unrelated healthy individuals. Polymorphism for the MMP-2 (rs2285053), MMP-3 (rs3025058) and MMP-7 (rs11568818) genes was genotyped by polymerase chain reaction-restriction enzyme length polymorphism.

Results: The frequencies of MMP-7 −181 G/G and A/G genotypes were found to be significantly higher in cancer patients compared with healthy controls (p=0.017). Stratification showed that individuals with MMP-7 −181 G allele were at increased risk for endometrial cancer when >50 years of age [odds ratios (OR)=2.03; 95% confidence interval (CI) 1.21–3.39], endometrioid (OR=1.80; 95% CI 1.11–2.92), low (stage I–II) (OR=1.73; 95% CI 1.05–2.83) or high stage (stage III–IV) (OR=2.69; 95% CI 1.16–6.24). Compared with the A/A genotype, the A/G+G/G genotype modified the risk of developing endometrial carcinoma and significance was detected in patients over 50 years old, and those with endometrioid type and high stage endometrial cancer. However, no significant difference in MMP-2 (-735 C/T) and MMP-3 (6A/5A) genotypes was observed between endometrial carcinoma cases and controls.

Conclusions: This is the first report on the association of MMP-2, MMP-3 and MMP-7 gene polymorphisms in endometrial cancer. Our results suggest that individuals with the MMP-7 −181 G/G and A/G genotype may have an increased risk of developing endometrial cancer.

Clin Chem Lab Med 2010;48:337–44.

Keywords: endometrial cancer; genetic polymorphism; matrix metalloproteinases

About the article

Corresponding authors: Shun-Fa Yang, PhD and Chih-Ping Han, MD, PhD, Institute of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo N. Road, Taichung, Taiwan, ROC Phone: +886-4-24739595/34253, Fax: +886-4-24723229, ;


Received: 2009-07-02

Accepted: 2009-11-17

Published Online: 2010-02-01

Published in Print: 2010-03-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 3, Pages 337–344, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.082.

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