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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 48, Issue 5


IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice

International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) – IFCC Scientific Division

Gerhard Schumann / Francesca Canalias
  • Laboratori de Referència d'Enzimologia Clínica, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Poul J. Joergensen / Dongchon Kang
  • Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jean-Marc Lessinger
  • Laboratoire de Biochimie appliqué e, Faculté de Pharmacie, Université Louis Pasteur, Illkirch, France
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/ Rainer Klauke / on behalf of the Committee on Reference Systems for Enzymes (C-RSE)
Published Online: 2010-03-19 | DOI: https://doi.org/10.1515/CCLM.2010.137


The primary reference measurement procedures (PRMPs) for the international standardization of catalytic concentration measurements of α-amylase, alanine aminotransferase, aspartate aminotransferase (AST), creatine kinase (CK), γ-glutamyltransferase and lactate dehydrogenase have been performed in reference laboratories for several years. The IFCC Committee on Reference Systems for Enzymes and two reference laboratories, with official accreditation for the PRMPs, have collected useful information on some of the steps of the reference procedures that require special attention. This document comprises errata corrige for minor mistakes in published PRMPs for AST and CK. Several notes on the PRMPs are emphasized. This includes details that are very important for improved standardization, and general suggestions for reducing measurement uncertainty.

Clin Chem Lab Med 2010;48:615–21.

Keywords: enzyme; IFCC; international standardization; primary reference measurement procedure

About the article

Corresponding author: Prof. Dr. Gerhard Schumann, Institut für Klinische Chemie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany Phone: +49(0)511 532 2523, Fax: +49(0)511 532 8523,

Received: 2010-01-13

Published Online: 2010-03-19

Published in Print: 2010-05-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 5, Pages 615–621, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.137.

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©2010 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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