Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982

Online
ISSN
1437-4331
See all formats and pricing
In This Section
Volume 48, Issue 6 (Jun 2010)

Issues

Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis

Joerg H. Holstein
  • Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
  • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
/ Markus Herrmann
  • Department of Clinical Chemistry and Laboratory Medicine, University of Saarland, Homburg/Saar, Germany
  • ANZAC Research Institute, University of Sydney, Sydney, Australia
/ Christina Splett
  • Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
  • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
/ Wolfgang Herrmann
  • Department of Clinical Chemistry and Laboratory Medicine, University of Saarland, Homburg/Saar, Germany
/ Patric Garcia
  • Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
  • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
/ Tina Histing
  • Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
  • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
/ Moritz Klein
  • Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
  • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
/ Karsten Kurz
  • Department of Orthopaedic Surgery, Knappschaftskrankenhaus Püttlingen, Püttlingen, Germany
/ Thomas Siebel
  • Department of Orthopaedic Surgery, Knappschaftskrankenhaus Püttlingen, Püttlingen, Germany
/ Tim Pohlemann
  • Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
/ Michael D. Menger
  • Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
Published Online: 2010-03-26 | DOI: https://doi.org/10.1515/CCLM.2010.155

Abstract

Background: Recent clinical and animal studies suggest that increased serum homocysteine (HCY) concentrations may be a risk factor for osteoporosis. In vitro studies showed that increasing HCY concentrations stimulate the activity of human osteoclasts. However, there is no data demonstrating that circulating HCY is related to structural and biomechanical properties of human bones. This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA).

Methods: Fasting blood samples and femoral heads were obtained from 94 males and females who underwent hip arthroplasty due to OA. Bones were assessed by dual energy X-ray absorptiometry (DXA), biomechanical testing (indentation method), and histomorphometry. Blood was collected for measurement of HCY, folate, vitamin B6, and vitamin B12. Subjects were classified as hyperhomocysteinemic (>12  μmol/L, n=47) and normohomocysteinemic (<12 μmol/L, n=47) according to their serum HCY concentrations.

Results: Folate and vitamin B6, but not vitamin B12, were significantly lower in hyperhomocysteinemic subjects compared with controls. However, DXA, biomechanical testing, and histomorphometry did not reveal significant differences in bone quality between hyperhomocysteinemic subjects and controls.

Conclusions: The results of the present study do not indicate a significant relationship between circulating HCY concentrations and morphological or biomechanical bone properties in humans with OA of the hip.

Clin Chem Lab Med 2010;48:821–7.

Keywords: biomechanics; bone mineral density; B vitamins; histomorphometry; hyperhomocysteinemia

About the article

Corresponding author: Joerg H. Holstein, MD, Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, 66421 Homburg/Saar, Germany Phone: +49-6841-16-31501, Fax: +49-6841-16-31503,


Received: 2009-08-25

Accepted: 2010-01-15

Published Online: 2010-03-26

Published in Print: 2010-06-01



Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.155. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Regan L. Bailey and Janneke P. van Wijngaarden
Current Osteoporosis Reports, 2015
[2]
Pooneh Salari, Mohammad Abdollahi, Ramin Heshmat, Hamidreza Meybodi, and Farideh Razi
DARU Journal of Pharmaceutical Sciences, 2014, Volume 22, Number 1, Page 62
[3]
Alexander Fisher, Wichat Srikusalanukul, Michael Davis, and Paul Smith
Stroke Research and Treatment, 2013, Volume 2013, Page 1
[4]
Vijay N. Joish, Grace Lin, and Richard Lynen
Journal of Medical Economics, 2012, Volume 15, Number 5, Page 807

Comments (0)

Please log in or register to comment.
Log in