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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 48, Issue 7


Reproductive-endocrine point-of-care testing: current status and limitations

Mark A. Cervinski
  • Department of Pathology, Dartmouth Medical School and Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ann M. Gronowski
  • Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-05-06 | DOI: https://doi.org/10.1515/CCLM.2010.183


Point-of-care (POC) testing for the detection of pregnancy and the prediction of ovulation has grown and evolved since the introduction of the first qualitative pregnancy test marketed directly to the consumer over three decades ago. Numerous publications have analyzed both pregnancy and ovulation prediction devices for their sensitivity, accuracy and general utility. Despite vast improvements in ease-of-use and sensitivity from their earlier forms, the primary literature regarding the utility of these devices is at times incomplete. This article reviews the literature focusing on the sensitivity and accuracy of the modern urine-luteinizing hormone ovulation prediction devices, and the effect these devices have on fertility rates. In addition, the analytical sensitivity and clinical utility of POC pregnancy tests will be reviewed, along with the potential causes of false negative and false positive results.

Clin Chem Lab Med 2010;48:935–42.

Keywords: diagnostic efficiency; human chorionic gonadotropin; luteinizing hormone; point-of-care

About the article

Corresponding author: Dr. Ann M. Gronowski, Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, St. Louis, MO 63110, USA Phone: +314-362-0194, Fax: +314-362-1461,

Published Online: 2010-05-06

Published in Print: 2010-07-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 7, Pages 935–942, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.183.

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