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Clinical Chemistry and Laboratory Medicine (CCLM)

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Cord blood and maternal serum neopterin concentrations in patients with pre-eclampsia

Tuncer Cayci1 / E. Ozgur Akgul1 / Yasemin Gulcan Kurt1 / Ibrahim Aydin1 / Hasan Alacam2 / Esin Ozkan1 / Halil Yaman1 / Erdinc Cakir1 / Ozgur Deren3 / Pakize Dogan2 / Cumhur Bilgi1 / M. Kemal Erbil1

1Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey

2Department of Medical Biochemistry, School of Medicine, Hacettepe University, Ankara, Turkey

3Department of Obstetrics and Gynecology, School of Medicine, Hacettepe University, Ankara, Turkey

Corresponding author: Halil Yaman, Department of Medical Biochemistry, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey Phone: +90 312 3043319, Fax: +90 312 3043300, ;

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Issue 8, Pages 1127–1131, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.213, May 2010

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Background: Pre-eclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study was to investigate neopterin concentrations in cord blood and maternal serum in patients with pre-eclampsia and a control group.

Methods: Cord blood and maternal serum neopterin were measured in 21 patients with pre-eclampsia and in 27 control subjects. Neopterin concentrations were measured by high performance liquid chromatography.

Results: Cord blood neopterin concentrations were significantly increased in patients with pre-eclampsia compared to controls (54.3±16.8 vs. 43.4±8.5 nmol/L, p=0.011, respectively). Maternal serum neopterin (257.3±36.8 vs. 150.9±33.8 nmol/L, p<0.001) was also higher in patients with pre-eclampsia.

Conclusions: Cord blood and maternal serum neopterin concentrations are higher in patients with pre-eclampsia. Maternal serum neopterin concentrations used may be used as a marker for the early diagnosis of pre-eclampsia.

Clin Chem Lab Med 2010;48:1127–31.

Keywords: cord blood; maternal serum; neopterin; pre-eclampsia

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