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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

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Volume 48, Issue 8 (Aug 2010)


Cord blood and maternal serum neopterin concentrations in patients with pre-eclampsia

Tuncer Cayci / E. Ozgur Akgul / Yasemin Gulcan Kurt / Ibrahim Aydin / Hasan Alacam / Esin Ozkan / Halil Yaman / Erdinc Cakir / Ozgur Deren
  • Department of Obstetrics and Gynecology, School of Medicine, Hacettepe University, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pakize Dogan / Cumhur Bilgi / M. Kemal Erbil
Published Online: 2010-05-04 | DOI: https://doi.org/10.1515/CCLM.2010.213


Background: Pre-eclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study was to investigate neopterin concentrations in cord blood and maternal serum in patients with pre-eclampsia and a control group.

Methods: Cord blood and maternal serum neopterin were measured in 21 patients with pre-eclampsia and in 27 control subjects. Neopterin concentrations were measured by high performance liquid chromatography.

Results: Cord blood neopterin concentrations were significantly increased in patients with pre-eclampsia compared to controls (54.3±16.8 vs. 43.4±8.5 nmol/L, p=0.011, respectively). Maternal serum neopterin (257.3±36.8 vs. 150.9±33.8 nmol/L, p<0.001) was also higher in patients with pre-eclampsia.

Conclusions: Cord blood and maternal serum neopterin concentrations are higher in patients with pre-eclampsia. Maternal serum neopterin concentrations used may be used as a marker for the early diagnosis of pre-eclampsia.

Clin Chem Lab Med 2010;48:1127–31.

Keywords: cord blood; maternal serum; neopterin; pre-eclampsia

About the article

Corresponding author: Halil Yaman, Department of Medical Biochemistry, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey Phone: +90 312 3043319, Fax: +90 312 3043300, ;

Received: 2010-01-07

Accepted: 2010-02-05

Published Online: 2010-05-04

Published in Print: 2010-08-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.213.

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©2010 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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