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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

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Source Normalized Impact per Paper (SNIP) 2017: 1.188

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1437-4331
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Volume 48, Issue 8

Issues

Human immunodeficiency virus-infection induces major changes in high-density lipoprotein particle size distribution and composition: the effect of antiretroviral treatment and disease severity

Gerard Aragonès
  • Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Universitat Rovira i Virgili, Spain
  • Other articles by this author:
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/ Raúl Beltrán-Debón
  • Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Universitat Rovira i Virgili, Spain
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/ Anna Rull
  • Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Universitat Rovira i Virgili, Spain
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/ Fernando Rodríguez-Sanabria
  • Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Universitat Rovira i Virgili, Spain
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/ Laura Fernández-Sender
  • Servei de Medicina Interna, Hospital Universitari Sant Joan de Reus, IISPV, Reus, Universitat Rovira i Virgili, Spain
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/ Jordi Camps
  • Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Universitat Rovira i Virgili, Spain
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/ Jorge Joven
  • Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Universitat Rovira i Virgili, Spain
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/ Carlos Alonso-Villaverde
  • Centre de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Universitat Rovira i Virgili, Spain
  • Servei de Medicina Interna, Hospital Universitari Sant Joan de Reus, IISPV, Reus, Universitat Rovira i Virgili, Spain
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Published Online: 2010-05-20 | DOI: https://doi.org/10.1515/CCLM.2010.218

Abstract

Background: Human immunodeficiency virus (HIV) infection is associated with abnormal high-density lipoprotein (HDL) particles. We evaluated whether HIV infection and antiretroviral treatment promotes changes in cholesterol distribution among subpopulations of HDL particles of defined sizes.

Methods: HDL particles were isolated from 78 HIV infected patients and fractionated by gel permeation chromatography to obtain five subpopulations. Thirty-six patients were antiretroviral treatment naïve, while 42 patients were treated with efavirenz or protease inhibitors. Uninfected individuals were also included as controls.

Results: The distribution of cholesterol across HDL particle sizes was affected by HIV infection itself. Antiretroviral therapy reduced these alterations; only minor changes in small and very small HDL particles were observed in treated patients (p=0.01). Untreated patients with low CD4+ T cell counts had less cholesterol in medium (p=0.006), small (p=0.04) and very small (p=0.03) HDL particles. Treated patients with high CD4+ T cell counts had less cholesterol in the largest HDL particles (p=0.04), with overall particle distributions resembling those observed in uninfected participants.

Conclusions: HIV infection itself may promote major changes in cholesterol distribution among HDL subpopulations that could be partially attenuated by current antiretroviral treatments. Further studies in larger populations are necessary to confirm the impact of HIV on lipoprotein composition and distribution.

Clin Chem Lab Med 2010;48:1147–52.

Keywords: antiretroviral therapy; CD4+ T cell; HIV infection; lipoprotein; particle size

About the article

Corresponding author: Carlos Alonso-Villaverde, Hospital Universitari Sant Joan, Sant Joan s/n, 43201-Reus, Spain Phone: +34 977 310 300, Fax: +34 977 319 984,


Received: 2009-12-07

Accepted: 2010-02-23

Published Online: 2010-05-20

Published in Print: 2010-08-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 8, Pages 1147–1152, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.218.

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