Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue

Issues

30,00 € / $42.00 / £23.00

Get Access to Full Text

Thyroglobulin measurement in fine-needle aspirates of lymph nodes in patients with differentiated thyroid cancer: a simple definition of the threshold value, with emphasis on potential pitfalls of the method

Claire Bournaud1, a / Anne Charrié2, a / Cécile Nozières1 / Karim Chikh2 / Véronique Lapras3 / Marie-Laure Denier4 / Christian Paulin5 / Myriam Decaussin-Petrucci5 / Jean-Louis Peix6 / Jean-Christophe Lifante6 / Catherine Cornu7 / Céline Giraud8 / Jacques Orgiazzi9 / Françoise Borson-Chazot1

1Hospices Civils de Lyon, Service Médecine Nucléaire, Groupement Hospitalier Est, Lyon, France

2Département de Biologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

3Hospices Civils de Lyon, Service de Radiologie, Hôpital Hôtel-Dieu, Lyon, France

4Hospices Civils de Lyon, Service de Radiologie, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

5Département d'Anatomie Pathologique, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

6Hospices Civils de Lyon, Service de Chirurgie Générale, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

7INSERM, CIC201, Lyon, France; CHU Lyon, Service de Pharmacologie Clinique, Lyon, France; Université Lyon, UMR 5558, Lyon, France

8INSERM, CIC201, Lyon, France

9Hospices Civils de Lyon, Service d'Endocrinologie, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

aC. Bournaud and A. Charrie contributed equally to this work.

Corresponding author: Dr. Anne Charrié, Centre de Biologie, Centre Hospitalier Lyon Sud, 165, chemin du Grand Revoyet, F-69495 Pierre Bénite Cedex, France Phone: +33 478 86 21 69, Fax: +33 478 86 66 54,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Issue 8, Pages 1171–1177, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.220, May 2010

Publication History

Received:
2009-09-24
Accepted:
2010-02-05
Published Online:
2010-05-04

Abstract

Background: Thyroglobulin measurements in fine-needle aspirate (FNA-Tg) is an accurate method for the diagnosis of lymph node metastasis in differentiated thyroid carcinoma. The goal of this study is to determine the most appropriate diagnostic threshold value for FNA-Tg.

Methods: Ultrasound-guided fine-needle aspiration-cytology (FNA-C) and FNA-Tg were performed on suspicious lymph nodes in 114 consecutive patients with thyroid cancer prior to thyroidectomy (n=13) or during follow-up (n=93), and in 16 control subjects. Functional sensitivity of the thyroglobulin assay was 0.7 ng/mL. Sensitivity and specificity of FNA-Tg and FNA-C were determined for different cut-off values within a range of 0.69–1.34 nanogram/punction (ng/p) using receiver operating characteristic curve analysis.

Results: The FNA-Tg cut-off value of 0.93 ng/p offers the best diagnostic performances: 94.2% sensitivity, 97.8% specificity. FNA-C showed 100% specificity in diagnostic samples, but low sensitivity of 71% due primarily to inadequate samples. Combining FNA-C and FNA-Tg resulted in 98% sensitivity and 100% specificity.

Conclusions: A unique threshold of 0.93 ng/p gives high sensitivity and specificity, even in non-thyroidectomized patients. However, since false negative results may be observed in poorly differentiated thyroid cancer, FNA-C should remain combined to FNA-Tg.

Clin Chem Lab Med 2010;48:1171–7.

Keywords: fine-needle aspiration; lymph node; thyroglobulin; thyroid cancer

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Cristina Familiar Casado, Teresa Antón Bravo, Inmaculada Moraga Guerrero, Araceli Ramos Carrasco, Carmen García García, and Santiago Villanueva Curto
Endocrinología y Nutrición (English Edition), 2013, Volume 60, Number 9, Page 495
[2]
Inyoung Youn, Ji Min Sung, Eun-Kyung Kim, and Jin Young Kwak
Ultrasound Quarterly, 2014, Volume 30, Number 4, Page 287
[3]
Maria Roseneide dos Santos Torres, Sebastião Horácio Nóbrega Neto, Rosalina Jenner Rosas, Aline Lemos Barros Martins, André Luis Correia Ramos, and Thomaz Rodrigues Porto da Cruz
Thyroid, 2014, Volume 24, Number 1, Page 7
[4]
Cristina Familiar Casado, Teresa Antón Bravo, Inmaculada Moraga Guerrero, Araceli Ramos Carrasco, Carmen García García, and Santiago Villanueva Curto
Endocrinología y Nutrición, 2013, Volume 60, Number 9, Page 495
[5]
Jeonghun Lee, Kuk Young Na, Jandee Lee, Su Jin Lee, Young Sil An, Joon Kee Yoon, and Euy Young Soh
Journal of the Korean Surgical Society, 2013, Volume 84, Number 4, Page 195
[6]
Qing Kay Li, Summer L. Nugent, Joely Straseski, David Cooper, Stefan Riedel, Frederic B. Askin, and Lori J. Sokoll
Cancer Cytopathology, 2013, Volume 121, Number 8, Page 440
[7]
Luca Giovanella, Massimo Bongiovanni, and Pierpaolo Trimboli
Current Opinion in Oncology, 2013, Volume 25, Number 1, Page 6
[9]
A. Georges, J.-B. Corcuff, J. Brossaud, and L. Bordenave
Médecine Nucléaire, 2012, Volume 36, Number 1, Page 24
[10]
Luca Giovanella, Luca Ceriani, and Sergio Suriano
Journal of Thyroid Research, 2011, Volume 2011, Page 1

Comments (0)

Please log in or register to comment.