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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

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1437-4331
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Volume 48, Issue 9 (Sep 2010)

Issues

Coeliac disease – a diagnostic and therapeutic challenge

Katri Kaukinen
  • Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
  • Medical School, University of Tampere, Tampere, Finland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Katri Lindfors / Pekka Collin
  • Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
  • Medical School, University of Tampere, Tampere, Finland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Outi Koskinen / Markku Mäki
  • Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-06-28 | DOI: https://doi.org/10.1515/CCLM.2010.241

Abstract

During the past 20 years the diagnosis of coeliac disease has improved significantly. However, at the same time the true prevalence of the condition has doubled, involving more than 2% of the population in some countries. Due to mild or atypical symptoms, the diagnosis remains a challenge for the health care system. Highly sensitive and specific serum endomysial and transglutaminase-2 antibody tests are helpful in identifying patients for diagnostic endoscopy and small-bowel biopsy. The diagnosis of the disease is still based on the demonstration of gluten-induced small-bowel mucosal villous atrophy with crypt hyperplasia. However, coeliac disease may manifest itself before the development of the overt small-intestinal lesion. Positive endomysial and transglutaminase antibodies in patients with normal small-bowel mucosal villous architecture may indicate early stage coeliac disease. Currently, the only effective treatment for the condition is a life-long strict gluten-free diet. Long-term regular follow-up of patients is recommended in order to maintain good adherence to the diet.

Clin Chem Lab Med 2010;48:1205–16.

Keywords: coeliac disease; dermatitis herpetiformis; gluten-free diet; malignancy; oats; transglutaminase-2; villous atrophy

About the article

Corresponding author: Dr. Katri Kaukinen, MD, PhD, Medical School, Finn-Medi 3, 33014 University of Tampere, Finland Phone: +358 3 3551 8403, Fax: +358 3 3551 8402,


Received: 2010-02-12

Accepted: 2010-03-14

Published Online: 2010-06-28

Published in Print: 2010-09-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.241.

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©2010 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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