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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 48, Issue 9

Issues

Rapid intraoperative parathyroid hormone assay in fine needle aspiration for differential diagnosis in thyroid and parathyroid surgery

Maria Rosa Pelizzo
  • Institution of Medical and Surgical Sciences, Department of Surgical Pathology, University Hospital of Padova, Padova, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Andrea Losi
  • Institution of Medical and Surgical Sciences, Department of Surgical Pathology, University Hospital of Padova, Padova, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Isabella Merante Boschin
  • Institution of Medical and Surgical Sciences, Department of Surgical Pathology, University Hospital of Padova, Padova, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Antonio Toniato
  • Institution of Medical and Surgical Sciences, Department of Surgical Pathology, University Hospital of Padova, Padova, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Gianmaria Pennelli / Nadia Sorgato
  • Institution of Medical and Surgical Sciences, Department of Surgical Pathology, University Hospital of Padova, Padova, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Diego Faggian / Mario Plebani
  • Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy
  • Leonardo Foundation, Abano Terme, Padova, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-07-07 | DOI: https://doi.org/10.1515/CCLM.2010.247

Abstract

Background: The purpose of our study was to investigate the efficacy of rapid intraoperative parathyroid hormone (rIO-PTH) analysis performed using material collected by fine needle aspiration as a parameter to distinguish anatomical structures which the surgeon is not able to identify clearly as parathyroid or lymph node during thyroid/parathyroid surgery. Before surgery, all patients gave written, informed consent.

Methods: We measured the rIO-PTH on 50 anatomical structures, 32 presumed parathyroids and 18 presumed lymph nodes from 22 patients, who underwent thyroid/parathyroid surgery between May and September 2009.

Results: The rIO-PTH values obtained on parathyroids ranged from 85.4 pmol/L to more than 2106 pmol/L, with a rIO-PTH median of 263.25 pmol/L. Results obtained on lymph nodes ranged from <0.52 pmol/L up to 20.4 pmol/L, with a rIO-PTH median equal to 1.31 pmol/L. Results of the Mann-Whitney test showed a rIO-PTH median significantly different (p<0.0001) between samples obtained from parathyroid glands and lymph node tissue.

Conclusions: We demonstrated that rapid intraoperative measurement of parathyroid hormone is a good parameter for the differential diagnosis of parathyroid vs. lymph node tissue. We suggest extending the use of this technique to the field of parathyroid preservation during thyroid/parathyroid surgery in those cases where the parathyroids prove difficult to recognize on the basis of topographic or morphologic criteria.

Clin Chem Lab Med 2010;48:1313–7.

Keywords: parathyroid preservation; parathyroidectomy; rapid intraoperative parathyroid hormone

About the article

Corresponding author: Isabella Merante Boschin, Department of Surgical Pathology, Medical and Surgical Sciences, University Hospital of Padova, Via Giustiniani 2, 35128 Padova, Italy Phone/Fax: +49 8212250,


Received: 2009-12-17

Accepted: 2010-03-12

Published Online: 2010-07-07

Published in Print: 2010-09-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 48, Issue 9, Pages 1313–1317, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2010.247.

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©2010 by Walter de Gruyter Berlin New York.Get Permission

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