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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 49, Issue 1 (Jan 2011)

Issues

Evaluation of ovarian cancer biomarkers in subjects with benign asbestos-related pleural diseases

Eun-Kee Park
  • Department of Thoracic Medicine, St. Vincent's Hospital, Darlinghurst, Sydney, NSW 2010, Australia
  • Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW 2031, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anthony R. Johnson / Deborah H. Yates
  • Department of Thoracic Medicine, St. Vincent's Hospital, Darlinghurst, Sydney, NSW 2010, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Paul S. Thomas
Published Online: 2010-10-20 | DOI: https://doi.org/10.1515/CCLM.2011.015

Abstract

Background: Mesothelioma and ovarian cancer have been reported to have a similar pathogenesis, and for this reason it was hypothesized that there may be biomarkers in common and possibly associated with benign pleural diseases caused by asbestos exposure.

Methods: Serum biomarkers including insulin-like growth factor-II (IGF-II), leptin, prolactin and vascular endothelial growth factor (VEGF) were measured in an observational study of subjects with benign asbestos-related pleural diseases (BARPD) (n=24) and healthy subjects with an asbestos exposure history (n=12).

Results: Mean serum IGF-II and VEGF concentration in healthy subjects with a history of asbestos exposure were higher than those with BARPD. Mean serum concentrations of leptin and prolactin showed opposite trends when compared to IGF-II and VEGF concentrations among these groups.

Conclusions: The results suggest that IGF-II and VEGF concentrations are lower in BARPD, similar to studies of ovarian cancer. This finding warrants further investigation with malignant asbestos-related diseases.

Keywords: asbestos; benign asbestos-related diseases; biomarker; ovarian cancer

About the article

Corresponding author: Paul S. Thomas, MD, Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia Phone: +61-2-9382-4620, Fax: +61-2-9382-4627


Received: 2010-05-04

Accepted: 2010-07-22

Published Online: 2010-10-20

Published in Print: 2011-01-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.015.

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©2011 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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