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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 49, Issue 1 (Jan 2011)

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Serum zinc-α2-glycoprotein concentrations in patients with non-alcoholic fatty liver disease

Yusuf Yilmaz
  • Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
  • Email:
/ Oya Yonal
  • Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
/ Fatih Eren
  • Institute of Gastroenterology, Marmara University, Maltepe, Istanbul, Turkey
/ Ramazan Kurt
  • Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
/ Cigdem Ataizi Celikel
  • Department of Pathology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
/ Osman Ozdogan
  • Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
/ Nese Imeryuz
  • Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
/ Cem Kalayci
  • Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
/ Erol Avsar
  • Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey
Published Online: 2010-11-16 | DOI: https://doi.org/10.1515/CCLM.2011.022

Abstract

Background: Evidence suggests that zinc-α2-glycoprotein (ZAG) might serve as a biomarker for human metabolic alterations. We measured serum ZAG in patients with non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, and examined its association with clinical, biochemical, and histological phenotypes.

Methods: Serum ZAG was determined using ELISA in 90 patients with biopsy-proven NAFLD and 81 controls.

Results: Serum ZAG concentrations did not differ in patients with NAFLD (median 61 μg/mL; interquartile range: 56–73 μg/mL) compared with healthy controls (median 66 μg/mL; interquartile range: 56–78 μg/mL, Mann-Whitney U-test, p=NS). However, among patients with NAFLD serum ZAG concentrations were significantly higher in males and in those with the metabolic syndrome. After stepwise linear regression analysis, serum ZAG concentrations were the only independent predictor of the number of metabolic syndrome components in patients with NAFLD (β=0.22; t=2.001, p<0.05).

Conclusions: In summary, the hypothesis of an association between NAFLD and serum ZAG concentrations is not supported by the present results. However, ZAG remains an interesting molecule for further research in the field of human metabolic disorders.

Keywords: enzyme-linked immunosorbent assay; non-alcoholic fatty liver disease; zinc-α2-glycoprotein

About the article

Corresponding author: Yusuf Yilmaz, MD, Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul 34662, Turkey Phone: +90-533-4403995, Fax: +90-216-6886681


Received: 2010-05-09

Accepted: 2010-07-28

Published Online: 2010-11-16

Published in Print: 2011-01-01



Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.022. Export Citation

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