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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Online
ISSN
1437-4331
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Volume 49, Issue 1 (Jan 2011)

Issues

Interaction between COX-2 G-765C and smoking in relation to coronary artery disease in a Chinese Uighur population

Xiang Xie
  • Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
/ Yi-Tong Ma
  • Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
  • Email:
/ Yi-Ning Yang
  • Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
/ Zhen-Yan Fu
  • Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
/ Xiao-Mei Li
  • Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
/ Ding Huang
  • Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
/ Xiang Ma
  • Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
/ Bang-dang Chen
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
/ Fen Liu
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P.R. China
Published Online: 2010-11-23 | DOI: https://doi.org/10.1515/CCLM.2011.024

Abstract

Background: Coronary artery disease (CAD) is a complex multifactorial and polygenic disorder where multiple environmental and genetic factors are involved simultaneously. The purpose of this study was to explore the relationship between the interaction of cyclooxygenase-2 (COX-2) gene polymorphism and smoking and CAD in a Uighur population.

Methods: Using a case-control study of Chinese Uighur CAD patients (n=430) and healthy controls (n=470), we investigated the roles of G-765C polymorphism in the COX-2 gene (PTGS2) by the use of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

Results: The PTGS2 GG genotype was significantly more prevalent in CAD patients (84.6% vs. 78.3%; p=0.014). Multiple logistic regression analysis showed two independent risk factors: smoking (OR 1.89, 95% CI 1.01–5.24; p=0.008) and hypertension (OR 2.73, 95% CI 1.59–7.21; p=0.001). Moreover, there was a synergistic effect between smoking and the PTGS2 polymorphism and the occurrence of CAD (interaction p=0.009). The odds ratio (OR) estimated by the combined analysis of the PTGS2 GG genotype and smoking history (OR 4.09, 95% CI 2.7–9.3) was markedly higher than that estimated separately from the PTGS2 GG genotype (OR 1.28, 95% CI 0.8–1.9) or smoking (OR 2.51, 95% CI 1.5–5.7) alone. Plasma 6-keto-PGF1α, a stable metabolite of PGI2, was lower in individuals with the PTGS2 GG genotype (p<0.05). Smoking could further lower plasma 6-keto-PGF1α concentrations in GG genotype carriers than non-smokers, especially in patients with CAD.

Conclusions: The PTGS2 polymorphism and smoking were synergistically and significantly associated in Chinese Uighur patients with CAD.

Keywords: coronary artery disease; cyclooxygenase-2; cytochrome P450; genetic polymorphism; smoking

About the article

Corresponding author: Yi-Tong Ma, Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R. China Phone: +86-991-4366169, Fax: +86-991-4364303/4366169


Received: 2010-03-16

Accepted: 2010-08-18

Published Online: 2010-11-23

Published in Print: 2011-01-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.024. Export Citation

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