Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 49, Issue 10 (Oct 2011)

Issues

Circulating tumor cells as emerging tumor biomarkers in breast cancer

Evi S. Lianidou / Athina Markou
  • Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-07-29 | DOI: https://doi.org/10.1515/CCLM.2011.628

Abstract

Circulating tumor cells (CTCs) provide unique information for the management of breast cancer patients, since their detection and monitoring is useful for prognosis, prediction of response to therapy, or monitoring clinical course in patients with localized or metastatic disease. Currently, the most practical application of CTCs is monitoring of patients with metastatic disease. Elevated CTC levels prior to initiation of a new systemic therapy are associated with a worse prognosis while persistently elevated CTC levels strongly suggest that the therapeutic regimen with which the patient is being treated is not working. New areas of research are directed toward developing novel sensitive assays for CTC molecular characterization. Molecular characterization of CTCs is very important for the future use of CTCs as targets of novel therapies. This review has focused on the presentation of recent data showing that CTCs are emerging as novel tumor biomarkers for prognostic and predictive purposes in breast cancer.

Keywords: breast cancer; circulating tumor cells; liquid biopsy; micrometastasis; mimal residual disease; tumor biomarkers

About the article

Corresponding author: Dr. Evi S. Lianidou, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens 15771, Greece Phone: +30 210 7274319, Fax: +30 210 7274750


Received: 2011-03-01

Accepted: 2011-05-02

Published Online: 2011-07-29

Published in Print: 2011-10-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.628.

Export Citation

©2011 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
[2]
ULRICH ANDERGASSEN, ALEXANDRA C. KÖLBL, SVEN MAHNER, and UDO JESCHKE
Oncology Reports, 2016, Volume 35, Number 4, Page 1905
[4]
Ivonne Nel, Thomas C. Gauler, Kira Bublitz, Lazaros Lazaridis, André Goergens, Bernd Giebel, Martin Schuler, Andreas-Claudius Hoffmann, and Min-Hsien Wu
PLOS ONE, 2016, Volume 11, Number 4, Page e0153018
[5]
Areti Strati, Sabine Kasimir-Bauer, Athina Markou, Cleo Parisi, and Evi S Lianidou
Breast Cancer Research, 2013, Volume 15, Number 2
[6]
V. K. Lyadov and V. V. Milovanov
Khirurgiya. Zhurnal im. N.I. Pirogova, 2016, Number 12, Page 93
[7]
Patrick Weller, Ivonne Nel, Philipp Hassenkamp, Thomas Gauler, Anke Schlueter, Stephan Lang, Paulette Dountsop, Andreas-Claudius Hoffmann, Götz Lehnerdt, and Andrew Yeudall
PLoS ONE, 2014, Volume 9, Number 12, Page e113706
[8]
Ana Vila, Miguel Abal, Laura Muinelo-Romay, Carlos Rodriguez-Abreu, José Rivas, Rafael López-López, Clotilde Costa, and Jung Weon Lee
PLOS ONE, 2016, Volume 11, Number 10, Page e0163705
[9]
Gary A. Clawson, Eric Kimchi, Susan D. Patrick, Ping Xin, Ramdane Harouaka, Siyang Zheng, Arthur Berg, Todd Schell, Kevin F. Staveley-O’Carroll, Rogerio I. Neves, Paul J. Mosca, Diane Thiboutot, and Rossella Rota
PLoS ONE, 2012, Volume 7, Number 7, Page e41052
[10]
Panagiota Economopoulou, Vassilis Georgoulias, and Athanasios Kotsakis
Expert Review of Molecular Diagnostics, 2017, Volume 17, Number 2, Page 153
[11]
Gordon M. Cann, Zulfiqar G. Gulzar, Samantha Cooper, Robin Li, Shujun Luo, Mai Tat, Sarah Stuart, Gary Schroth, Sandhya Srinivas, Mostafa Ronaghi, James D. Brooks, AmirAli H. Talasaz, and Natasha Kyprianou
PLoS ONE, 2012, Volume 7, Number 11, Page e49144
[12]
Daniel L. Adams, R. Katherine Alpaugh, Stuart S. Martin, Monica Charpentier, Saranya Chumsri, Massimo Cristofanilli, Diane K. Adams, Olga V. Makarova, Peixuan Zhu, Shuhong Li, Cha-Mei Tang, and Steingrimur Stefansson
RSC Adv., 2016, Volume 6, Number 8, Page 6405
[13]
Daniel L. Adams, Peixuan Zhu, Olga V. Makarova, Stuart S. Martin, Monica Charpentier, Saranya Chumsri, Shuhong Li, Platte Amstutz, and Cha-Mei Tang
RSC Adv., 2014, Volume 4, Number 9, Page 4334
[14]
[15]
Thore Hillig, Ann-Britt Nygaard, Laura Nekiunaite, Jörg Klingelhöfer, and György Sölétormos
APMIS, 2014, Volume 122, Number 6, Page 545
[16]
Alison M. McDonnell, Andrew J. Currie, Matthew Brown, Kasia Kania, Ben Wylie, Amanda Cleaver, Richard Lake, and Bruce W.S. Robinson
OncoImmunology, 2012, Volume 1, Number 6, Page 840
[17]
Shiu-Ru Lin, Ming-Yii Huang, and Ming-Sung Chang
Biomarkers and Genomic Medicine, 2013, Volume 5, Number 1-2, Page 12
[18]
Rongxiang He, Libo Zhao, Yumin Liu, Nangang Zhang, Boran Cheng, Zhaobo He, Bo Cai, Sizhe Li, Wei Liu, Shishang Guo, Yong Chen, Bin Xiong, and Xing-Zhong Zhao
Biomedical Microdevices, 2013, Volume 15, Number 4, Page 617
[19]
Tobias M. Gorges and Klaus Pantel
Cancer Immunology, Immunotherapy, 2013, Volume 62, Number 5, Page 931
[20]
Evi S. Lianidou, Athina Markou, and Areti Strati
Cancer and Metastasis Reviews, 2012, Volume 31, Number 3-4, Page 663
[21]
Artur A. Antoniewicz, Agnieszka Paziewska, Michal Mikula, Krzysztof Goryca, Michalina Dabrowska, Slawomir Poletajew, Andrzej Borowka, and Jerzy Ostrowski
International Urology and Nephrology, 2012, Volume 44, Number 3, Page 761
[22]
Tsvetana Hristozova, Robert Konschak, Volker Budach, and Ingeborg Tinhofer
Cytometry Part A, 2012, Volume 81A, Number 6, Page 489
[23]
Gaetano Aurilio, Angela Sciandivasci, Elisabetta Munzone, Maria Teresa Sandri, Laura Zorzino, Maria Cristina Cassatella, Elena Verri, Maria Cossu Rocca, and Franco Nolè
Expert Review of Anticancer Therapy, 2012, Volume 12, Number 2, Page 203
[24]
Bohuslav Melichar and Mario Plebani
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 10

Comments (0)

Please log in or register to comment.
Log in