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Clinical Chemistry and Laboratory Medicine (CCLM)

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In This Section
Volume 49, Issue 11 (Nov 2011)


Oxidative stress and diabetes mellitus

Hui Yang
  • Department of Laboratory Medicine, China-Japan Friendship Hospital, Ministry of Health, Beijing, P.R. China
/ Xun Jin
  • Department of Laboratory Medicine, China-Japan Friendship Hospital, Ministry of Health, Beijing, P.R. China
/ Christopher Wai Kei Lam
  • Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, P.R. China
/ Sheng-Kai Yan
  • Department of Laboratory Medicine, China-Japan Friendship Hospital, Ministry of Health, Beijing, P.R. China
  • Guang Zhou Improve Medical Instruments Co., Ltd, Guangzhou, P.R. China
Published Online: 2011-08-03 | DOI: https://doi.org/10.1515/cclm.2011.250


Increasing evidences have suggested that oxidative stress plays a major role in the pathogenesis of diabetes mellitus (DM). Oxidative stress also appears to be the pathogenic factor in underlying diabetic complications. Reactive oxygen species (ROS) are generated by environmental factors, such as ionizing radiation and chemical carcinogens, and also by endogenous processes, including energy metabolism in mitochondria. ROS produced either endogenously or exogenously can attack lipids, proteins and nucleic acids simultaneously in living cells. There are many potential mechanisms whereby excess glucose metabolites traveling along these pathways might promote the development of DM complication and cause pancreatic β cell damage. However, all these pathways have in common the formation of ROS, that, in excess and over time, causes chronic oxidative stress, which in turn causes defective insulin gene expression and insulin secretion as well as increased apoptosis. Various methods for determining biomarkers of cellular oxidative stress have been developed, and some have been proposed for sensitive assessment of antioxidant defense and oxidative damage in diabetes and its complications. However, their clinical utility is limited by less than optimal standardization techniques and the lack of sufficient large-sized, multi-marker prospective trials.

Keywords: advanced glycation endproducts; diabetes mellitus; oxidative stress; reactive nitrogen species; reactive oxygen species

About the article

Corresponding author: Dr. Sheng-Kai Yan, Department of Laboratory Medicine, China-Japan Friendship Hospital, Ministry of Health, No. 2 East Yinghua Road, Chaoyang District, Beijing 100029, P.R. China Phone: +86-10-84205213, Fax: +86-10-64288578,

Received: 2010-09-02

Accepted: 2011-06-01

Published Online: 2011-08-03

Published in Print: 2011-11-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.250. Export Citation

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