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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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1437-4331
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Volume 49, Issue 11 (Nov 2011)

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Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia

Gergely Toldi
  • First Department of Pediatrics, Semmelweis University, Budapest, Hungary
  • Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary
/ Edina Bíró
  • Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary
/ Balázs Szalay
  • First Department of Pediatrics, Semmelweis University, Budapest, Hungary
  • Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary
/ Balázs Stenczer
  • First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
/ Attila Molvarec
  • First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
/ János Rigó Jr
  • First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
/ Barna Vásárhelyi
  • Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary
  • Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary
/ Gabriella Bekõ
  • Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary
Published Online: 2011-07-04 | DOI: https://doi.org/10.1515/cclm.2011.656

Abstract

Background: Preeclampsia is characterized by a maternal systemic inflammatory response and the impairment of maternal immune tolerance present in healthy pregnancy. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the monitoring of systemic inflammation. We aimed to assess the levels of suPAR and other markers of systemic inflammation in preeclampsia compared to healthy pregnancy.

Methods: We determined plasma suPAR, IL-6 and high sensitivity C-reactive protein (hs-CRP) levels in plasma samples of 62 healthy pregnant and 41 preeclamptic women in the third trimester of pregnancy.

Results: Plasma suPAR levels were elevated in preeclampsia [3.18 (2.30–4.71) ng/mL vs. 2.02 (1.81–2.40) ng/mL, p=0.0001, median (interquartile range)]. IL-6 and hs-CRP levels were also higher compared with healthy pregnancy [5.99 (2.97–18.12) pg/mL vs. 1.41 (1.00–2.70) pg/mL, p=0.0001 and 6.60 (3.55–15.40) mg/L vs. 3.90 (2.10–7.25) mg/L, p=0.006, respectively, median (interquartile range)]. Linear regression analyses revealed an association between individual plasma suPAR and log IL-6 levels as well as log hs-CRP levels.

Conclusions: suPAR levels are elevated in preeclampsia and vary in a narrower range compared with IL-6 and hs-CRP. ROC analysis indicated that monitoring of suPAR levels is a suitable tool for the detection of systemic inflammation in pregnancy.

Keywords: high sensitivity C-reactive protein; IL-6; preeclampsia; pregnancy; suPAR

About the article

Corresponding author: Gergely Toldi, First Department of Pediatrics, Semmelweis University, Budapest, Bókay u. 53-54, 1083, Hungary Phone: +36-20-4367181, Fax: +36-1-3138212,


Received: 2011-04-29

Accepted: 2011-05-23

Published Online: 2011-07-04

Published in Print: 2011-11-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.656. Export Citation

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